(R)-1-Arylethanols have been prepared in high to excellent overall yields through a two-step one-pot process that involves the palladium-catalyzed conversion of aryl iodides into the corresponding acetophenones, in the presence of acetic anhydride. EtN(i-Pr)(2), LiCl, and Pd(2)(dba)(3) followed by an enantioselective reduction step catalyzed by the alcohol dehydrogenase enzyme from Lactobacillus brevis. (C) 2009 Elsevier B.V. All rights reserved.
(R)-1-Arylethanols from aryl iodides through a two-step one-pot enantioselective chemoenzymatic process / Cacchi, Sandro; Roberto, Cirilli; Fabrizi, Giancarlo; Simona, Sgalla; Macone, Alberto; Bonamore, Alessandra; Boffi, Alberto. - In: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. - ISSN 1381-1177. - 61:3-4(2009), pp. 184-187. [10.1016/j.molcatb.2009.06.009]
(R)-1-Arylethanols from aryl iodides through a two-step one-pot enantioselective chemoenzymatic process
CACCHI, Sandro;FABRIZI, Giancarlo;MACONE, ALBERTO;BONAMORE, ALESSANDRA;BOFFI, Alberto
2009
Abstract
(R)-1-Arylethanols have been prepared in high to excellent overall yields through a two-step one-pot process that involves the palladium-catalyzed conversion of aryl iodides into the corresponding acetophenones, in the presence of acetic anhydride. EtN(i-Pr)(2), LiCl, and Pd(2)(dba)(3) followed by an enantioselective reduction step catalyzed by the alcohol dehydrogenase enzyme from Lactobacillus brevis. (C) 2009 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
