Notch signaling pathway regulates a wide variety of cellular processes during development and it also plays a crucial role in human diseases. This important link is firmly established in cancer, since a rare T-ALL-associated genetic lesion has been initially reported to result in deletion of Notch1 ectodomain and constitutive activation of its intracellular region. Interestingly, the cellular response to Notch signaling can be extremely variable depending on the cell type and activation context. Notch signaling triggers signals implicated in promoting carcinogenesis and autoimmune diseases, whereas it can also sustain responses that are critical to suppress carcinogenesis and to negatively regulate immune response. However, Notch signaling induces all these effects via an apparently simple signal transduction pathway, diversified into a complex network along evolution from Drosophila to mammals. Indeed, an explanation of this paradox comes from a number of evidences accumulated during the last few years, which dissected the intrinsic canonical and non-canonical components of the Notch pathway as well as several modulatory extrinsic signaling events. The identification of these signals has shed light onto the mechanisms whereby Notch and other pathways collaborate to induce a particular cellular phenotype. In this article, we review the role of Notch signaling in cells as diverse as T lymphocytes and epithelial cells of the epidermis, with the main focus on understanding the mechanisms of Notch versatility. (C) 2008 Elsevier B.V. All rights reserved.

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes / Talora, Claudio; Campese, Antonio Francesco; Bellavia, Diana; Felli, MARIA PIA; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella. - In: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE. - ISSN 0925-4439. - STAMPA. - 1782:9(2008), pp. 489-497. [10.1016/j.bbadis.2008.06.008]

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

TALORA, Claudio;CAMPESE, Antonio Francesco;BELLAVIA, Diana;FELLI, MARIA PIA;VACCA, Alessandra;GULINO, Alberto;SCREPANTI, Isabella
2008

Abstract

Notch signaling pathway regulates a wide variety of cellular processes during development and it also plays a crucial role in human diseases. This important link is firmly established in cancer, since a rare T-ALL-associated genetic lesion has been initially reported to result in deletion of Notch1 ectodomain and constitutive activation of its intracellular region. Interestingly, the cellular response to Notch signaling can be extremely variable depending on the cell type and activation context. Notch signaling triggers signals implicated in promoting carcinogenesis and autoimmune diseases, whereas it can also sustain responses that are critical to suppress carcinogenesis and to negatively regulate immune response. However, Notch signaling induces all these effects via an apparently simple signal transduction pathway, diversified into a complex network along evolution from Drosophila to mammals. Indeed, an explanation of this paradox comes from a number of evidences accumulated during the last few years, which dissected the intrinsic canonical and non-canonical components of the Notch pathway as well as several modulatory extrinsic signaling events. The identification of these signals has shed light onto the mechanisms whereby Notch and other pathways collaborate to induce a particular cellular phenotype. In this article, we review the role of Notch signaling in cells as diverse as T lymphocytes and epithelial cells of the epidermis, with the main focus on understanding the mechanisms of Notch versatility. (C) 2008 Elsevier B.V. All rights reserved.
2008
autoimmunity; lymphomagenesis; notch signaling; skin cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes / Talora, Claudio; Campese, Antonio Francesco; Bellavia, Diana; Felli, MARIA PIA; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella. - In: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE. - ISSN 0925-4439. - STAMPA. - 1782:9(2008), pp. 489-497. [10.1016/j.bbadis.2008.06.008]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/224173
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 42
  • Scopus 72
  • ???jsp.display-item.citation.isi??? 69
social impact