The effects of acetylsalicylic acid (ASA) indometacin and ditazole on prostacyclin production from rabbit aortic rings were studied in comparison to their inhibiting activity on platelet aggregation. The result were expressed as the ratio between the drug dose inhibiting by 50% prostacycline production and the minimum oral antiaggregating dose. The following ratios were found: 2.4 for ASA, 7.3 for indometacin and 20.4 for ditazole
Activity ratio between anti-prostacyclin and antiaggregating effects of acetylsalicylic acid, indomethacin and ditazole / Caprino, Luciano; Togna, Giuseppina Ines; Antonetti, F; Borrelli, F.. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 30:(1980), pp. 406-409.
Activity ratio between anti-prostacyclin and antiaggregating effects of acetylsalicylic acid, indomethacin and ditazole
CAPRINO, Luciano;TOGNA, Giuseppina Ines;
1980
Abstract
The effects of acetylsalicylic acid (ASA) indometacin and ditazole on prostacyclin production from rabbit aortic rings were studied in comparison to their inhibiting activity on platelet aggregation. The result were expressed as the ratio between the drug dose inhibiting by 50% prostacycline production and the minimum oral antiaggregating dose. The following ratios were found: 2.4 for ASA, 7.3 for indometacin and 20.4 for ditazoleI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
