In this paper we show some applications of Advanced and Parallel Computing to the study of mathematical models in Systems Biology and in particular of the networks of biochemical reactions occurring inside a cell. Due to their high complexity, the numerical study of these systems must be approached by means of sophisticated Advanced Computing tools. Two examples are shown: in a deterministic framework, the application of Optimal Control techniques to the study of the effects of a drug on a cell; in the stochastic framework, the adaptation of the Gillespie algorithm to the so called total quasi steady-state approximation (tQSSA).
Systems Biology and Advanced Computing / Bersani, Alberto Maria; P., Lanucara; M., Rorro; V., Ruggiero. - STAMPA. - 133:(2007), pp. 11-20. (Intervento presentato al convegno MASCOT07-IMACS/ISGG WORKSHOP tenutosi a Roma nel 13-14/09/2007).
Systems Biology and Advanced Computing
BERSANI, Alberto Maria;
2007
Abstract
In this paper we show some applications of Advanced and Parallel Computing to the study of mathematical models in Systems Biology and in particular of the networks of biochemical reactions occurring inside a cell. Due to their high complexity, the numerical study of these systems must be approached by means of sophisticated Advanced Computing tools. Two examples are shown: in a deterministic framework, the application of Optimal Control techniques to the study of the effects of a drug on a cell; in the stochastic framework, the adaptation of the Gillespie algorithm to the so called total quasi steady-state approximation (tQSSA).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
