[4]Heterohelicenium cations la-c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations la-c have been resolved by HPLC using water-based eluents containing KPF6 as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte: structure on retention and enantioselectivity was investigated.
HPLC Resolution of Chiral [4]Heterohelicenium Dyes on Chiral Stationary Phases / Laleau, B; Mobian, P; Lacour, J; Villani, Claudio. - --:8(2006), pp. -----. (Intervento presentato al convegno 17th International Symposium on Chirality tenutosi a Parma; Italy nel 11-14/9/2005).
HPLC Resolution of Chiral [4]Heterohelicenium Dyes on Chiral Stationary Phases
VILLANI, Claudio
2006
Abstract
[4]Heterohelicenium cations la-c adopt a twisted helical structure that renders them chiral. They are configurationally stable and their enantiomers have been resolved, for the first time, by HPLC on Chiralcel OD-RH and Chirobiotic TAG chiral stationary phases (CSPs). Chiral cations la-c have been resolved by HPLC using water-based eluents containing KPF6 as additive. The elution order of the analyte enantiomers was determined by on-line CD detection, and was found to be opposite on the two CSPs. The effect of mobile phase composition and analyte: structure on retention and enantioselectivity was investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
