In phototransduction, there is experimental evidence of considerable fluctuations in the current as a response of the rod to single photon events. We propose that the location of the activation site is one of the components responsible for such a fluctuation. We have created a mathematical model of this system which is capable of detecting activation sites and tracing the dependence of the current profiles on such locations. Using such a mathematical and computational model, we have analyzed the variation in the global current drop, and then compared it to the variation of the existing experimental data. The overall conclusions are that the location of the activation site is, at least partially, responsible for the fluctuations of the current response. © 2005 American Institute of Physics.
Fluctuations of the single photon response in visual transduction / Lixin, Shen; Andreucci, Daniele. - In: AIP CONFERENCE PROCEEDINGS. - ISSN 0094-243X. - STAMPA. - 780:(2005), pp. 553-556. (Intervento presentato al convegno NOISE AND FLUCTUATIONS: 18th International Conference on Noise and Fluctuations - ICNF 2005 tenutosi a Salamanca; Spain nel 19 September 2005 through 23 September 2005) [10.1063/1.2036813].
Fluctuations of the single photon response in visual transduction
ANDREUCCI, Daniele
2005
Abstract
In phototransduction, there is experimental evidence of considerable fluctuations in the current as a response of the rod to single photon events. We propose that the location of the activation site is one of the components responsible for such a fluctuation. We have created a mathematical model of this system which is capable of detecting activation sites and tracing the dependence of the current profiles on such locations. Using such a mathematical and computational model, we have analyzed the variation in the global current drop, and then compared it to the variation of the existing experimental data. The overall conclusions are that the location of the activation site is, at least partially, responsible for the fluctuations of the current response. © 2005 American Institute of Physics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
