A series of sodium salts of antibiotics belonging to the cephalosporin group has been analyzed by such thermoanalytical techniques as TG, DTG and DSC. No melting processes have been identified. The heating process, mainly carried out in a stream of oxygen, shows thermal reactions starting at about 150°C. Sodium sulphate was found as residue at temperatures around 600–650°C. From the residue, which has a well-defined composition, it is possible to dose the sodium to a higher degree of accuracy than that obtained by flame photometry. In addition, the analytical time required for pretreatment of the sample is shorter.
Application of thermal analytical methods to pharmaceutical products. Cephalosporins / BIADER CEIPIDOR, Ugo; Curini, Roberta; Tomassetti, Mauro. - In: THERMOCHIMICA ACTA. - ISSN 0040-6031. - STAMPA. - 56:2(1982), pp. 125-133. [10.1016/0040-6031(82)85133-2]
Application of thermal analytical methods to pharmaceutical products. Cephalosporins
BIADER CEIPIDOR, Ugo;CURINI, Roberta;TOMASSETTI, Mauro
1982
Abstract
A series of sodium salts of antibiotics belonging to the cephalosporin group has been analyzed by such thermoanalytical techniques as TG, DTG and DSC. No melting processes have been identified. The heating process, mainly carried out in a stream of oxygen, shows thermal reactions starting at about 150°C. Sodium sulphate was found as residue at temperatures around 600–650°C. From the residue, which has a well-defined composition, it is possible to dose the sodium to a higher degree of accuracy than that obtained by flame photometry. In addition, the analytical time required for pretreatment of the sample is shorter.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
