In the last few years mechatronic implantable drug delivery systems have been found to be suitable for a large variety of applications for the treatment of pathologies such as cancer, diabetes or neurological diseases. In particular, a large part of the aforementioned pathologies asks for direct drug delivery at brain level. Unfortunately, the field of biomechatronic systems fitted for a direct infusion of drugs into the brain is still in its infancy. In this paper, as a design starting point, we examine a conventional system for drug delivery against typical medical requirements for brain applications; then we try and define the architecture of a biomechatronic system for drug delivery into the cerebral compartment, taking into account the close interaction with the anatomical compartment and its physiological constraints. A model of the whole system is proposed, and some simulation results are given, together with a simple control strategy.
A general model for guiding the design of biomechatronic systems implantable into the brain / S., Petroni; D., Accoto; M., Campolo; Annesini, Maria Cristina; E., Guglielmelli. - 2006:(2006), pp. 371-376. (Intervento presentato al convegno 1st IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006, BioRob 2006 tenutosi a Pisa nel 20 February 2006 through 22 February 2006) [10.1109/biorob.2006.1639115].
A general model for guiding the design of biomechatronic systems implantable into the brain
ANNESINI, Maria Cristina;
2006
Abstract
In the last few years mechatronic implantable drug delivery systems have been found to be suitable for a large variety of applications for the treatment of pathologies such as cancer, diabetes or neurological diseases. In particular, a large part of the aforementioned pathologies asks for direct drug delivery at brain level. Unfortunately, the field of biomechatronic systems fitted for a direct infusion of drugs into the brain is still in its infancy. In this paper, as a design starting point, we examine a conventional system for drug delivery against typical medical requirements for brain applications; then we try and define the architecture of a biomechatronic system for drug delivery into the cerebral compartment, taking into account the close interaction with the anatomical compartment and its physiological constraints. A model of the whole system is proposed, and some simulation results are given, together with a simple control strategy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
