While isolated REM sleep Behavior Disorder (iRBD) is primarily de!ned by REM-related dysregulation, emerging evidence suggests that NREM sleep, particularly Slow Wave Sleep (SWS), plays a crucial role in neuroprotection and metabolic clearance. This study investigates whether speci !c electrophysiological markers in NREM sleep, such as K-complexes (KC) and Slow Wave Activity (SWA), can serve as early biomarkers for cognitive decline in iRBD.
Bad Slow Waves and Good Slow Waves? A Functional-Multimodal Analysis for Disentangling Deep Sleep in RBD / Galbiati, A., Gorgoni, M., Scarpelli, S., Leitner, C., Carli, G., Fasiello, E., Alfonsi, V., Pietrogiacomi, F., Reda, F., Camaioni, M., Frillocchi, V., Pellegrini, E., Casoni, F., Marelli, S., De Gennaro, L., Ferini- Strambi, L.. - In: JOURNAL OF SLEEP RESEARCH. - ISSN 0962-1105. - 35:S1(2026). [10.1111/jsr.70434]
Bad Slow Waves and Good Slow Waves? A Functional-Multimodal Analysis for Disentangling Deep Sleep in RBD
Maurizio Gorgoni;Serena Scarpelli;Flaminia Reda;Milena Camaioni;Valentina Frillocchi;Elisa Pellegrini;Luigi De Gennaro;
2026
Abstract
While isolated REM sleep Behavior Disorder (iRBD) is primarily de!ned by REM-related dysregulation, emerging evidence suggests that NREM sleep, particularly Slow Wave Sleep (SWS), plays a crucial role in neuroprotection and metabolic clearance. This study investigates whether speci !c electrophysiological markers in NREM sleep, such as K-complexes (KC) and Slow Wave Activity (SWA), can serve as early biomarkers for cognitive decline in iRBD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
