IRIDE (Innovative RadIation Dose Estimation for pediatric retinoblastoma treatment en- hancement) aims to enhance 106Ru brachytherapy for pediatric retinoblastoma, the most common childhood eye tumor. While brachytherapy effectively treats localized tumors and preserves vision using radioactive plaques, the lack of patient-specific 3D treatment planning limits dosimetric accuracy. The development of a simulation-based algorithm could improve dose personalization and accessibility. IRIDE addresses this by developing a Geant4 Monte Carlo (MC) treatment planning tool. It personalizes and optimizes dosimetry incorporating 3D dose profiles with diagnostic tumor imaging. The innovation lies in simulating individual particle tracks rather than using conventional dosimetric algorithms. For validation, the simulation incorporated a digital eye phantom from the 4D XCAT library and a modeled CCX plaque based on manufacturer data. This enabled successful 3D dose profile recon- struction on realistic anatomical data. Future steps will integrate the actual plaque surface activity distribution, measured via a custom robotic detector, to achieve highly accurate, personalized pediatric dosimetry.
The IRIDE project: a Monte Carlo tool for improving brachytherapy treatment of pediatric retinoblastoma / Antonini, M., Avella, S., Caccia, B., Cannatà, V., Carruezzo, M., Ciucci, D., Polito, C., Pozzi, S., Solfaroli Camillocci, E., De Simoni, M.. - (2026), pp. 83-83. (112° CONGRESSO NAZIONALE Società Italiana di Fisica Firenze ).
The IRIDE project: a Monte Carlo tool for improving brachytherapy treatment of pediatric retinoblastoma.
Antonini M.;Avella S.;Carruezzo M.;Solfaroli Camillocci E.;De Simoni M.
2026
Abstract
IRIDE (Innovative RadIation Dose Estimation for pediatric retinoblastoma treatment en- hancement) aims to enhance 106Ru brachytherapy for pediatric retinoblastoma, the most common childhood eye tumor. While brachytherapy effectively treats localized tumors and preserves vision using radioactive plaques, the lack of patient-specific 3D treatment planning limits dosimetric accuracy. The development of a simulation-based algorithm could improve dose personalization and accessibility. IRIDE addresses this by developing a Geant4 Monte Carlo (MC) treatment planning tool. It personalizes and optimizes dosimetry incorporating 3D dose profiles with diagnostic tumor imaging. The innovation lies in simulating individual particle tracks rather than using conventional dosimetric algorithms. For validation, the simulation incorporated a digital eye phantom from the 4D XCAT library and a modeled CCX plaque based on manufacturer data. This enabled successful 3D dose profile recon- struction on realistic anatomical data. Future steps will integrate the actual plaque surface activity distribution, measured via a custom robotic detector, to achieve highly accurate, personalized pediatric dosimetry.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
