An abnormal immune response at the fetal-maternal interface is expected in 50–60 % of unexplained Recurrent Pregnancy Loss (uRPL) cases. Detected immunophenotypes in uRPL could help in risk assessment, prognosis and therapy. The study of immune mechanisms at the fetal-maternal interface is crucial, but the technique used for research has limitations, including contamination and invasiveness, which can trigger immune responses. Hystero-embryoscopy may provide a precise method for studying the immunological factors involved in RPL at the maternal-fetal interface, reducing bias from sample collection techniques. Our aim is to assess its effectiveness in obtaining high-quality samples to study the immunological basis of RPL.
Hystero-embryoscopy as a tool for RPL immunological research at the maternal-fetal interface / Bruno, V., Zizolfi, B., Ferretti, M., Di Martino, S., Maria Arteni Brindusa, A., Betti, M., Ciuffreda, L., De Nicola, F., Scalera, S., Cariati, F., De Angelis, C., Nardelli, F., Giudice, M., Mancini, E., Baiocco, E., Russo, M., Pallocca, M., Fanciulli, M., Piaggio, G., Carosi, M., et al.. - In: PLACENTA. - ISSN 0143-4004. - 168:(2025), pp. 28-34. [10.1016/j.placenta.2025.05.026]
Hystero-embryoscopy as a tool for RPL immunological research at the maternal-fetal interface
Valentina Bruno
;Margherita Ferretti;Martina Betti;Federica Cariati;Ermelinda Baiocco;Matteo Pallocca;Maurizio Fanciulli;
2025
Abstract
An abnormal immune response at the fetal-maternal interface is expected in 50–60 % of unexplained Recurrent Pregnancy Loss (uRPL) cases. Detected immunophenotypes in uRPL could help in risk assessment, prognosis and therapy. The study of immune mechanisms at the fetal-maternal interface is crucial, but the technique used for research has limitations, including contamination and invasiveness, which can trigger immune responses. Hystero-embryoscopy may provide a precise method for studying the immunological factors involved in RPL at the maternal-fetal interface, reducing bias from sample collection techniques. Our aim is to assess its effectiveness in obtaining high-quality samples to study the immunological basis of RPL.| File | Dimensione | Formato | |
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Note: 10.1016/j.placenta.2025.05.026
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