Digital treatment planning and clear aligners therapy: Current evidence-based perspectives in growing patients — A narrative review with case reports

The mixed dentition phase represents a fundamental step for guiding occlusal development and address- ing dento-skeletal discrepancies in growing patients. Among available modalities, clear aligners (CA) have emerged as a viable option in Phase I therapy, offering benefits in terms of aesthetics, hygiene, and com- fort. The present narrative review explores current evidence on CA therapy in growing patients and anal- yses the biomechanical issues of CA therapy. Two clinical cases are presented to illustrate treatment pro- tocols highlighting the importance of customized digital planning in the application of CA in early or- thodontic intervention to obtain aesthetic and functional results.