Background: Direct oral anticoagulants (DOACs) reduce thromboembolism in atrial fibrillation (AF), but their effect on cardiac outcomes is less studied. Methods: Systematic review and network meta-analysis were performed on AF patients on DOACs/vitamin K antagonists (VKAs). Both observational studies and randomized clinical trials (RCTs) were included. Endpoints were myocardial infarction (MI) and major adverse cardiac events (MACE). Rankograms and SUCRA were performed. Sub-group analysis included age (
Effects of direct oral anticoagulants on cardiac outcomes in atrial fibrillation: a systematic review and network meta-analysis / Menichelli, D., Malatesta, D., Pannunzio, A., Farcomeni, A., Violi, F., Pignatelli, P., Pastori, D.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - (2026). [10.1007/s11739-026-04480-1]
Effects of direct oral anticoagulants on cardiac outcomes in atrial fibrillation: a systematic review and network meta-analysis
Menichelli, DaniloPrimo
;Malatesta, Daniele;Pannunzio, Arianna;Farcomeni, Alessio;Violi, Francesco;Pignatelli, Pasquale;Pastori, Daniele
Ultimo
2026
Abstract
Background: Direct oral anticoagulants (DOACs) reduce thromboembolism in atrial fibrillation (AF), but their effect on cardiac outcomes is less studied. Methods: Systematic review and network meta-analysis were performed on AF patients on DOACs/vitamin K antagonists (VKAs). Both observational studies and randomized clinical trials (RCTs) were included. Endpoints were myocardial infarction (MI) and major adverse cardiac events (MACE). Rankograms and SUCRA were performed. Sub-group analysis included age (I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
