A mild, efficient, eco-friendly method for the regioselective halogenation of arylboronic acids in water has been reported. A transition-metal-free ipso-chlorination of arylboronic acids was performed in water, yielding aryl chlorides. Ipsobrominated and iodinated compounds were obtained under the same conditions using the corresponding halide salts. This ecofriendly method operates efficiently, even on activated or nonactivated systems, with good yields and selectivity
NCS-Mediated Ipso-Halogenation of Arylboronic Acids in Water Using Sodium Halides / Santarsiere, A., Galgano, P., Funicello, M., Lupattelli, P., Chiummiento, L.. - In: ACS OMEGA. - ISSN 2470-1343. - 10:(2025), pp. 27856-27860. [10.1021/acsomega.5c00755]
NCS-Mediated Ipso-Halogenation of Arylboronic Acids in Water Using Sodium Halides
Paolo Lupattelli;
2025
Abstract
A mild, efficient, eco-friendly method for the regioselective halogenation of arylboronic acids in water has been reported. A transition-metal-free ipso-chlorination of arylboronic acids was performed in water, yielding aryl chlorides. Ipsobrominated and iodinated compounds were obtained under the same conditions using the corresponding halide salts. This ecofriendly method operates efficiently, even on activated or nonactivated systems, with good yields and selectivity| File | Dimensione | Formato | |
|---|---|---|---|
|
Santersiere_NCS-Mediated_2025.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
2.34 MB
Formato
Adobe PDF
|
2.34 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
