Multiple bilobar liver metastases from uveal melanoma: What is the limit for surgical resection?

The primary clinical factor influencing survival in uveal melanoma (UM) is the onset of liver metastases. Managing uveal melanoma liver metastases (UMLM) remains difficult, as conventional systemic therapies infrequently yield durable responses and are linked with poor outcomes. Nonetheless, liver surgery continues to be the preferred strategy for improving prognosis in patients with potentially resectable metastases. Additionally, under certain conditions, debulking of the tumor has demonstrated effectiveness in delaying hepatic metastatic disease progression when it is technically achievable. This report describes our surgical approach to bilobar liver metastases from UM with hepatic vein infiltration, emphasizing both surgical techniques and outcomes, and explores the potential for maximal tumor reduction in UMLM following an extended disease-free interval between primary UM treatment and liver metastasis detection.