Methyltrioxorhenium (MTO) is a useful and selective catalyst for the oxidation of uracil and purine derivatives using environmentally friendly hydrogen peroxide (H2O2, 30% water solution) or hydrogen peroxide/urea adduct (UHP) as oxygen atom donors. In particular, the MTO/UHP system constitutes a convenient combination to convert uracil derivatives into the biologically relevant 5,6- oxiranyl-5,6-dihydrouracils in good yields. Purine derivatives are selectively oxidized to the corresponding 1-oxides, the best yield being obtained in the presence of pyrazine-2-carboxylic acid (PCA). The oxidation of the plasmid pBG1 is also reported as the ®rst example of double-strand DNA cleavage mediated by the catalytic system MTO/H2O2.
Selective oxidation of uracil and adenine derivatives by the catalytic system MeReO3/, H2O2 and MeReO3/Urea hydrogen peroxide / Saladino, R., P., C., Danti, M.C., C., C., E., M.. - In: TETRAHEDRON. - ISSN 0040-4020. - 56/51:(2000), pp. 10031-10037.
Selective oxidation of uracil and adenine derivatives by the catalytic system MeReO3/, H2O2 and MeReO3/Urea hydrogen peroxide
SALADINO R;
2000
Abstract
Methyltrioxorhenium (MTO) is a useful and selective catalyst for the oxidation of uracil and purine derivatives using environmentally friendly hydrogen peroxide (H2O2, 30% water solution) or hydrogen peroxide/urea adduct (UHP) as oxygen atom donors. In particular, the MTO/UHP system constitutes a convenient combination to convert uracil derivatives into the biologically relevant 5,6- oxiranyl-5,6-dihydrouracils in good yields. Purine derivatives are selectively oxidized to the corresponding 1-oxides, the best yield being obtained in the presence of pyrazine-2-carboxylic acid (PCA). The oxidation of the plasmid pBG1 is also reported as the ®rst example of double-strand DNA cleavage mediated by the catalytic system MTO/H2O2.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
