A general and convenient method for the synthesis of several pyrimidine and purine nucleosides by selective oxidn. of thionucleosides with dimethyldioxirane is reported. Thioketo moieties in the C-4 position of the pyrimidine ring, and in the C-6, and C-8 positions of the purine ring are the domain of oxidative nucleophilic substitution. Thioketo moieties in the C-2 position of both purine and pyrimidine rings are the domain of desulfurization or formation of disulfides
Transformations of thiopyrimidine and thiopurine nucleosides / Saladino, R., E., M., C., C., M., M.. - In: TETRAHEDRON. - ISSN 0040-4020. - 52:(1996), pp. 6759-6780. [10.1016/0040-4020(96)00289-X]
Transformations of thiopyrimidine and thiopurine nucleosides
SALADINO R;
1996
Abstract
A general and convenient method for the synthesis of several pyrimidine and purine nucleosides by selective oxidn. of thionucleosides with dimethyldioxirane is reported. Thioketo moieties in the C-4 position of the pyrimidine ring, and in the C-6, and C-8 positions of the purine ring are the domain of oxidative nucleophilic substitution. Thioketo moieties in the C-2 position of both purine and pyrimidine rings are the domain of desulfurization or formation of disulfidesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
