Alkylation of RNA oligonucleotides by the aminoalcohols 2-amino-2-hydroxymethyl-propane-1,3-diol(commonly known as Tris-base)and 2-amino-2-methyl-1-propanol has been observed in strongly acidic environments. There action occurs according to a carbocationic mechanism and is time-,temperature-,concentration-and,strictly,pH-dependent.Our results suggest that aminoalcohols present in the prebiotic mix could not only alter the chemical composition of the oligonucleotides formed on dry landunder hydrothermal conditions,but,more importantly,they could protect the first informational polymers from degradation.
Stabilization of Short Oligonucleotides in the Prebiotic Mix: The Potential Role of Amino Alcohols / Pino, S., Di mauro, E., Costanzo, G., Saladino, R., Šedo, O., Zdráhal, Z., Šponer, J., Šponer, J.E.. - In: CHEMSYSTEMSCHEM. - ISSN 2570-4206. - 6:(2019). [doi.org/10.1002/syst.201900006]
Stabilization of Short Oligonucleotides in the Prebiotic Mix: The Potential Role of Amino Alcohols
Saladino R;
2019
Abstract
Alkylation of RNA oligonucleotides by the aminoalcohols 2-amino-2-hydroxymethyl-propane-1,3-diol(commonly known as Tris-base)and 2-amino-2-methyl-1-propanol has been observed in strongly acidic environments. There action occurs according to a carbocationic mechanism and is time-,temperature-,concentration-and,strictly,pH-dependent.Our results suggest that aminoalcohols present in the prebiotic mix could not only alter the chemical composition of the oligonucleotides formed on dry landunder hydrothermal conditions,but,more importantly,they could protect the first informational polymers from degradation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
