Abstract: Vicinal halohydrins are key building blocks toproduce bioactivemolecules anddrugs, especially if theycanbeobtained inenantiomerically pure form. In this study, we present a bienzymatic sequence that allows to obtain vichalohydrins throughaphotochemoenzymaticolefin hydroxyhalogenationfollowedbyalipasecatalysed kineticresolution.Theabsoluteconfigurationof the resultingproductswas determinedusingMosher’s method
Synthesis of enantiopure vicinal halohydrins using a sequence of haloperoxidase and lipase / De Marchi, E., Hilberath, T., Zippilli, C., Wever, R., Saladino, R., Hollmann, F., Botta, L.. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - 366:15(2024), pp. 3290-3296. [10.1002/adsc.202400516]
Synthesis of enantiopure vicinal halohydrins using a sequence of haloperoxidase and lipase
Saladino, Raffaele;
2024
Abstract
Abstract: Vicinal halohydrins are key building blocks toproduce bioactivemolecules anddrugs, especially if theycanbeobtained inenantiomerically pure form. In this study, we present a bienzymatic sequence that allows to obtain vichalohydrins throughaphotochemoenzymaticolefin hydroxyhalogenationfollowedbyalipasecatalysed kineticresolution.Theabsoluteconfigurationof the resultingproductswas determinedusingMosher’s method| File | Dimensione | Formato | |
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