Everolimus (EVE) is a mammalian target of rapamycin inhibitor (mTOR-I) widely used in transplantation that may determine some severe adverse events, including pulmonary fibrosis. The pathogenic mechanism of mTOR-I-associated pulmonary toxicity is still unclear, but epithelial to mesenchymal transition (EMT) of bronchial/pulmonary cells may play a role.

Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation / Tomei, P., Masola, V., Granata, S., Bellin, G., Carratù, P., Ficial, M., Ventura, V.A., Onisto, M., Resta, O., Gambaro, G., Chilosi, M., Lupo, A., Zaza, G.. - In: JN. JOURNAL OF NEPHROLOGY. - ISSN 1121-8428. - 29:6(2016), pp. 881-891. [10.1007/s40620-016-0295-4]

Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation

Zaza, Gianluigi
2016

Abstract

Everolimus (EVE) is a mammalian target of rapamycin inhibitor (mTOR-I) widely used in transplantation that may determine some severe adverse events, including pulmonary fibrosis. The pathogenic mechanism of mTOR-I-associated pulmonary toxicity is still unclear, but epithelial to mesenchymal transition (EMT) of bronchial/pulmonary cells may play a role.
2016
Cystic fibrosis; Epithelial-mesenchymal transition; Everolimus; Fibrosis; Lung; Pulmonary cells; mTOR inhibitor
01 Pubblicazione su rivista::01a Articolo in rivista
Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation / Tomei, P., Masola, V., Granata, S., Bellin, G., Carratù, P., Ficial, M., Ventura, V.A., Onisto, M., Resta, O., Gambaro, G., Chilosi, M., Lupo, A., Zaza, G.. - In: JN. JOURNAL OF NEPHROLOGY. - ISSN 1121-8428. - 29:6(2016), pp. 881-891. [10.1007/s40620-016-0295-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1764325
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