The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g. Crohn’s disease and rheumatoid arthritis) and of organ transplant recipients. As inactive prodrugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine require intracellular activation, catalyzed by multiple enzymes, to exert cytotoxicity.

Thiopurine pathway / Zaza, G., Cheok, M., Krynetskaia, N., Thorn, C., Stocco, G., Hebert, J.m., Mcleod, H., Weinshilboum, R.m., Relling, M.v., Evans, W.e., Klein, T.e., Altman, R.B.. - In: PHARMACOGENETICS AND GENOMICS. - ISSN 1744-6872. - 20:9(2010), pp. 573-574. [10.1097/FPC.0b013e328334338f]

Thiopurine pathway

Zaza, Gianluigi;
2010

Abstract

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g. Crohn’s disease and rheumatoid arthritis) and of organ transplant recipients. As inactive prodrugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine require intracellular activation, catalyzed by multiple enzymes, to exert cytotoxicity.
2010
acute lymphoblastic leukemia; azathioprine; 6-mercaptopurine; 6-thioguanine; thiopurine; thiopurine S-methyltransferase
01 Pubblicazione su rivista::01a Articolo in rivista
Thiopurine pathway / Zaza, G., Cheok, M., Krynetskaia, N., Thorn, C., Stocco, G., Hebert, J.m., Mcleod, H., Weinshilboum, R.m., Relling, M.v., Evans, W.e., Klein, T.e., Altman, R.B.. - In: PHARMACOGENETICS AND GENOMICS. - ISSN 1744-6872. - 20:9(2010), pp. 573-574. [10.1097/FPC.0b013e328334338f]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1764288
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