The introduction of pediatric-like regimes and risk-adapted strategies mostly based on measurable residual disease (MRD) has significantly improved the prognosis of Philadelphia-negative (Ph–) acute lymphoblastic leukemia (ALL) in younger adults.1-3 However, older patients still experience a poor outcome with standard chemotherapy, with a notable risk of early death, toxicities and relapse. Pediatric-inspired regimens are feasible in older adults with encouraging results, but dose adaptations are mandatory and asparaginase toxicity represents a significant challenge.
Real-life management of 476 older adults with Philadelphia-negative acute lymphoblastic leukemia: a Campus ALL study / Cerrano, M., Lazzarotto, D., Boscaro, E., Borlenghi, E., Tanasi, I., Chiusolo, P., Minetto, P., Grimaldi, F., Giglio, F., Dargenio, M., Leoncin, M., Trappolini, S., Papayannidis, C., Forghieri, F., Gurrieri, C., Zappasodi, P., La Starza, R., Fracchiolla, N., Di Biase, F., Del Principe, M.I., et al.. - In: HAEMATOLOGICA. - ISSN 1592-8721. - (2026), pp. 3088-3092. [10.3324/haematol.2025.288555]
Real-life management of 476 older adults with Philadelphia-negative acute lymphoblastic leukemia: a Campus ALL study
Grimaldi, Francesco;La Starza, Roberta;Mariani, Sabrina;Annunziata, Mario;Pasquini, Andrea;Antonacci, Marco;Fumagalli, Monica;Chiaretti, Sabina;Foà, Robin;
2026
Abstract
The introduction of pediatric-like regimes and risk-adapted strategies mostly based on measurable residual disease (MRD) has significantly improved the prognosis of Philadelphia-negative (Ph–) acute lymphoblastic leukemia (ALL) in younger adults.1-3 However, older patients still experience a poor outcome with standard chemotherapy, with a notable risk of early death, toxicities and relapse. Pediatric-inspired regimens are feasible in older adults with encouraging results, but dose adaptations are mandatory and asparaginase toxicity represents a significant challenge.| File | Dimensione | Formato | |
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Cerrano_Real-life-management_2026.pdf
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Cerrano_supplementary_Real-life-management_2026.pdf
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Note: Supplementary appendix
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