Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.
Elevation of tTG-IgA antibodies in a prospective cohort of children at risk of celiac disease. Insights from the CDGEMM cohort / Pucinischi, V., Kenyon, V., Montuori, M., Piemontese, P., Francavilla, R., Norsa, L., Di Nardo, G., Baldassarre, M.E., Trovato, M.C., Perrone, M., Passaro, T., Sansotta, N., Crocco, M., Morelli, A., Malerba, F., Cristofori, F., Elli, L., Fasano, A., Valitutti, F., Leonard, M.M., et al.. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 121:2(2026), pp. 554-556. [10.14309/ajg.0000000000003772]
Elevation of tTG-IgA antibodies in a prospective cohort of children at risk of celiac disease. Insights from the CDGEMM cohort
Pucinischi, Valentina;Montuori, Monica;Di Nardo, Giovanni;Trovato, Maria Chiara;Perrone, Michela;Morelli, Annalisa;Valitutti, Francesco;
2026
Abstract
Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.| File | Dimensione | Formato | |
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