Standard therapeutic options for localized prostate cancer (PCa) include whole gland treatment such as radical prostatectomy (RP) or radiation, administered according to various protocols. These treatments may result in erectile and urinary dysfunction in 50% or more of patients. Active surveillance (AS) does not affect functional outcomes and should be offered to patients presenting with low-risk and favorable intermediate-risk PCa. Due to improved risk stratification and increasing use of multiparametric Magnetic Resonance Imaging (mpMRI) in PCa follow-up, the cancer survival of patients on AS is not affected if appropriate follow-up is done. Focal therapy (FT) represents an alternative between radical therapies and observation. Regretfully, it is not recommended in many guidelines despite its good safety profile and the demonstrated superiority of post treatment erectile and urinary functions rates. This reflects the lack of randomized trials and limited data on long term oncologic outcomes
Imaging in focal therapy: advanced ultrasound imaging and mpMRI-a comprehensive review / Correas, Jean-Michel; Dariane, Charles; Renard Penna, Raphaele; Ghai, Sangeet; Bladou, Franck; Cathelineau, Xavier; Ward, John F; Emberton, Mark; Laguna, Pilar; Chiu, Peter; De Nunzio, Cosimo; Klotz, Laurence; Futterer, Jurgen; De La Rosette, Jean. - In: PROSTATE CANCER AND PROSTATIC DISEASES. - ISSN 1365-7852. - (2025). [10.1038/s41391-025-01017-z]
Imaging in focal therapy: advanced ultrasound imaging and mpMRI-a comprehensive review
de Nunzio, Cosimo;
2025
Abstract
Standard therapeutic options for localized prostate cancer (PCa) include whole gland treatment such as radical prostatectomy (RP) or radiation, administered according to various protocols. These treatments may result in erectile and urinary dysfunction in 50% or more of patients. Active surveillance (AS) does not affect functional outcomes and should be offered to patients presenting with low-risk and favorable intermediate-risk PCa. Due to improved risk stratification and increasing use of multiparametric Magnetic Resonance Imaging (mpMRI) in PCa follow-up, the cancer survival of patients on AS is not affected if appropriate follow-up is done. Focal therapy (FT) represents an alternative between radical therapies and observation. Regretfully, it is not recommended in many guidelines despite its good safety profile and the demonstrated superiority of post treatment erectile and urinary functions rates. This reflects the lack of randomized trials and limited data on long term oncologic outcomesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
