Electrospun coatings are emerging as an alternative to conventional titanium-based implant surface modifications. Here, we developed poly (lactic acid) (PLA)/nano-hydroxyapatite (nHAp) nanofibrous coatings deposited on titanium by electrospinning. A dimethyl carbonate/acetone (1:1 ratio) solvent system was adopted as a safer and sustainable alternative to toxic solvents. Scanning electron microscopy showed uniform fibers with diameters below 550 nm and coating thicknesses of 35–45 µm. FTIR spectra confirmed nHAp incorporation through characteristic phosphate bands. In vitro degradation revealed greater weight loss and more pronounced pH reduction for PLA/nHAp coatings. These green-fabricated bioactive coatings represent a promising strategy to enhance titanium implant integration.

Biocompatible PLA/nHAp coatings for titanium implants fabricated by green electrospinning / Ciarleglio, Gianluca; Toto, Elisa; Laurenzi, Susanna; Santonicola, Maria Gabriella. - In: MRS COMMUNICATIONS. - ISSN 2159-6867. - (2025), pp. 1-7. [10.1557/s43579-025-00891-x]

Biocompatible PLA/nHAp coatings for titanium implants fabricated by green electrospinning

Ciarleglio, Gianluca
Primo
;
Toto, Elisa;Laurenzi, Susanna;Santonicola, Maria Gabriella
Ultimo
2025

Abstract

Electrospun coatings are emerging as an alternative to conventional titanium-based implant surface modifications. Here, we developed poly (lactic acid) (PLA)/nano-hydroxyapatite (nHAp) nanofibrous coatings deposited on titanium by electrospinning. A dimethyl carbonate/acetone (1:1 ratio) solvent system was adopted as a safer and sustainable alternative to toxic solvents. Scanning electron microscopy showed uniform fibers with diameters below 550 nm and coating thicknesses of 35–45 µm. FTIR spectra confirmed nHAp incorporation through characteristic phosphate bands. In vitro degradation revealed greater weight loss and more pronounced pH reduction for PLA/nHAp coatings. These green-fabricated bioactive coatings represent a promising strategy to enhance titanium implant integration.
2025
electrospinning; poly(lactic acid); nanofibers; biomaterial; bioactive coatings; hydroxyapatite
01 Pubblicazione su rivista::01a Articolo in rivista
Biocompatible PLA/nHAp coatings for titanium implants fabricated by green electrospinning / Ciarleglio, Gianluca; Toto, Elisa; Laurenzi, Susanna; Santonicola, Maria Gabriella. - In: MRS COMMUNICATIONS. - ISSN 2159-6867. - (2025), pp. 1-7. [10.1557/s43579-025-00891-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1756305
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