Inflammatory response to various implant surfaces in murine models: A systematic analysis

Breast implants (BIs) are commonly used in cosmetic and reconstructive breast surgery but are linked to several complications such as capsular contracture, implant rupture, and potential malignancies. The key to mitigating these issues is the exploration of host-implant interactions, especially in response to the diverse BI surface textures, classified under ISO 14607:2018 standards. We aimed to systematically analyze the effects of different BI surface textures on inflammatory response and capsule formation in murine models, to improve BI design and clinical outcomes. A PRISMA-guided systematic review was conducted across 4 databases, focusing on murine model studies related to BI surface variations. Non-murine, human studies and those involving physical or pharmacological interventions were excluded. Implant surfaces were categorized per ISO 14607:2018, including smooth, microtextured, macrotextured, and polyurethane foam- coated (PU) BI, and compared with new ISO 14607:2018. Outcomes were assessed on capsule characteristics, inflammatory patterns, and biomechanical properties. Smooth-surfaced implants were linked to thinner, more orderly capsules, with a subdued inflammatory reaction. Microtextured implants elicited a moderate response with varying tissue integration and inflammation levels. Macrotextured implants showed pronounced tissue