Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al.1 present an efficient method for differentiating human pluripotent stem cells into A10-like mDA neurons. Activation of grafted A10-like neurons into the mouse mesolimbic circuit alleviates depression-like symptoms.
Engineered VTA dopaminergic neurons offer a new path to treating depression / Ventura, Rossella. - In: CELL STEM CELL. - ISSN 1934-5909. - 32:9(2025), pp. 1313-1314. [10.1016/j.stem.2025.08.007]
Engineered VTA dopaminergic neurons offer a new path to treating depression
Ventura, Rossella
Primo
2025
Abstract
Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al.1 present an efficient method for differentiating human pluripotent stem cells into A10-like mDA neurons. Activation of grafted A10-like neurons into the mouse mesolimbic circuit alleviates depression-like symptoms.File allegati a questo prodotto
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