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INTRODUCTION: Hospital-acquired bloodstream infections (HA-BSIs) are severe and require antibiotic therapy. In non-complicated BSIs, shortened therapy reduces side effects without compromising efficacy. The impact of shortened antibiotic therapy in HA-BSI critically ill patients without indication of prolonged therapy requires further evaluation. METHODS: Using the international prospective EUROBACT-2 cohort, we compared shortened (7-10 days) versus long (14-21 days) treatment durations in ICU patients eligible for shortened therapy. Patients without antibiotic therapy within 3 days after HA-BSI occurrence or requiring prolonged therapy (due to infection source, microorganism, or clinical deterioration) were excluded. Treatment failure, defined as death, persistent infection, or subsequent infectious complications by Day 28, was assessed using an inverse-probability of treatment weighted (IPTW) logistic regression. RESULTS: Among 2600 patients, 550 were eligible for shortened treatment, 213 received short, and 337 received long treatment. The most common infection source was intravascular catheters (33%), most common microorganisms were Enterobacterales (39%). Patients with long treatment were more frequently infected with Staphylococcus aureus (11% vs. 5.6%, p = 0.025) or difficult-to-treat microorganisms (23% vs. 7%, p < 0.001), and received more commonly combination therapy (46% vs. 30%, p < 0.001). Short treatment was associated with reduced 28-day treatment failure (OR 0.64, 95% CI 0.44-0.93, p = 0.019), mainly due to reduction in subsequent infectious complications (OR 0.58, 95% CI 0.37-0.91, p = 0.018). Mortality (OR 0.92 [95% CI 0.59, 1.43], p = 0.7) and persistent infection rates (OR 0.47 [95% CI 0.17, 1.14], p = 0.12) were similar. CONCLUSIONS: In selected ICU patients with HA-BSI, shortened antibiotic treatment might be considered. Eurobact2 was a prospective international cohort study, registered in ClinicalTrials.org (NCT03937245).

Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database / Lena, Gajdos; Niccolo, Buetti; Alexis, Tabah; Stephane, Ruckly; Murat, Akova; Frederik, Sjöval; Kostoula, Arvaniti; Jan, De Waele; Hendrik, Bracht; Francois, Barbier; Timsit, ; Alexis Tabah, Jean-François; Lipman, Jeffrey; Tabah, Alexis; Pollock, Hamish; Margetts, Ben; Udy, Andrew; Young, Meredith; Bhadange, Neeraj; Tyler, Steven; Ledtischke, Anne; Finnis, Mackenzie; Ledtischke, Anne; Finnis, Mackenzie; Dwivedi, Jyotsna; Saxena, Manoj; Biradar, Vishwanath; Soar, Natalie; Sarode, Vineet; Brewster, David; Regli, Adrian; Weeda, Elizabeth; Ahmed, Samiul; Fourie, Cheryl; Laupland, Kevin; Ramanan, Mahesh; Walsham, James; Meyer, Jason; Litton, Edward; Maria Palermo, Anna; Yap, Timothy; Eroglu, Ege; George Attokaran, Antony; Jaramillo, C'Havala; Mk Nafees, Khalid; Mahmood Khan Nafees, Khalid; Aqilah Haji Abd Rashid, Nurhikmahtul; Adi Muhamad Ibnu Walid, Haji; Mon, Tomas; Dhakshina Moorthi, P; Sudhirchandra, Shah; Damodar Sridharan, Dhadappa; Haibo, Qiu; Xie, Jianfeng; Haibo, Qiu; Jianfeng, Xie; Wei-Hua, Lu; Zhen, Wang; Qian, Chuanyun; Luo, Jili; Chen, Xiaomei; Wang, Hao; Zhao, Peng; Zhao, Juan; Wusi, Qiu; Mingmin, Chen; Xu, Lei; Yin, Chengfen; Wang, Ruilan; Wang, Jinfeng; Yin, Yongjie; Zhang, Min; Ye, Jilu; Hu, Chungfang; Zhou, Suming; Huang, Min; Yan, Jing; Wang, Yan; Qin, Bingyu; Ye, Ling; Weifeng, Xie; Peije, Li; Geng, Nan; Ling, Lowell; Ling, Lowell; Hayashi, Yoshiro; Hayashi, Yoshiro; Karumai, Toshiyuki; Yamasaki, Masaki; Hashimoto, Satoru; Hosokawa, Koji; Makino, Jun; Matsuyoshi, Takeo; Kuriyama, Akira; Shigemitsu, Hidenobu; Mishima, Yuka; Nagashima, Michio; Yoshida, Hideki; Fujitani, Shigeki; Omori, Koichiro; Rinka, Hiroshi; Saito, Hiroki; Atobe, Kaori; Kato, Hideaki; Takaki, Shunsuke; Sulaiman, Helmi; Shahnaz Hasan, M; Fadhil Hadi Jamaluddin, Muhamad; See Pheng, Lee; Visvalingam, Sheshendrasurian; Thing Liew, Mun; Ling Danny Wong, Siong; Khang Fong, Kean; Bt Abdul Rahman, Hamizah; Md Noor, Zuraini; Kok Tong, Lee; Hamid Azman, Abd; Zulfakar Mazlan, Mohd; Ali, Saedah; Mark Hernandez, Aaron; Abello, Anton; Jeon, Kyeongman; Jeon, Kyeongman; Lee, Sang-Min; Park, Sunghoon; Yong Park, Seung; Yoon Lim, Sung; Lay Hoon Kwa, Andrea; Yuan Goh, Qing; Yuan Goh, Qing; Yi Ng, Shin; An Lie, Sui; Lay Hoon Kwa, Andrea; Junyang Goh, Ken; Yunkai Li, Andrew; Yu Ming Ong, Caroline; Yan Lim, Jia; Lishan Quah, Jessica; Ng, Kangqi; Yu-Chang Yeh, Tony; Chang Yeh, Yu; Chou, Nai-Kuan; Cia, Cong-Tat; Hu, Ting-Yu; Kuo, Li-Kuo; Ku, Shih-Chi; Wongsurakiat, Phunsup; Wongsurakiat, Phunsup; Apichatbutr, Yutthana; Chiewroongro, Supattra; Alsisi, Adel; Nadeem, Rashid; El Houfi, Ashraf; Alsisi, Adel; Alsisi, Adel; Elhadidy, Amr; Barsoum, Mina; Osman, Nermin; Mostafa, Tarek; Elbahnasawy, Mohamed; Saber, Ahmed; Aldhalia, Amer; Elmandouh, Omar; Elsayed, Ahmed; A Elbadawy, Merihan; K Awad, Ahmed; M Hemead, Hanan; Zand, Farid; Zand, Farid; Ouhadian, Maryam; Hamid Borsi, Seyed; Mehraban, Zahra; Kashipazha, Davood; Ahmadi, Fatemeh; Savaie, Mohsen; Soltani, Farhad; Rashidi, Mahboobeh; Baghbanian, Reza; Javaherforoosh, Fatemeh; Amiri, Fereshteh; Kiani, Arash; Amin Zargar, Mohammad; Mahmoodpoor, Ata; Aalinezhad, Fatemeh; Dabiri, Gholamreza; Sabetian, Golnar; Sarshad, Hakimeh; Masjedi, Mansoor; Tajvidi, Ramin; Mohammad Nasirodin Tabatabaei, Seyed; Khudhur Ahmed, Abdullah; Singer, Pierre; Singer, Pierre; Kagan, Ilya; Rigler, Merav; Belman, Daniel; Levin, Phillip; Harara, Belal; Diab, Adei; Abillama, Fayez; Abilama, Fayez; Ibrahim, Rebecca; Fares, Aya; Elhadi, Muhammed; Buimsaedah, Ahmad; Gamra, Marwa; Aqeelah, Ahmed; Mohammed Aliali, Almajdoub; Gaber Sadik Homaidan, Ahmed; Almiqlash, Bushray; Bilkhayr, Hala; Bouhuwaish, Ahmad; Sa Taher, Ahmed; Abdulwahed, Eman; A Abousnina, Fathi; Khaled Hdada, Aisha; Jobran, Rania; Ben Hasan, Hayat; Shaban Ben Hasan, Rabab; Abidi, Khalid; Serghini, Issam; Seddiki, Rachid; Boukatta, Brahim; Kanjaa, Nabil; Mouhssine, Doumiri; Ahmed Wajdi, Maazouzi; Dendane, Tarek; Ali Zeggwagh, Amine; Housni, Brahim; Younes, Oujidi; Hachimi, Abdelhamid; Ghannam, A; Belkhadir, Z; Amro, Sarah; Abu Jayyab, Mustafa; Aithssain, Ali; Ait Hssain, Ali; Elbuzidi, Abdurahaman; Karic, Edin; Lance, Marcus; Nissar, Shaikh; Sallam, Hend; Elrabi, Omar; A Almekhlafi, Ghaleb; Awad, Maher; Aljabbary, Ahmed; Karam Chaaban, Mohammad; Abu-Sayf, Natalia; Al-Jadaan, Mohammad; Bakr, Lubna; Bouaziz, Mounir; Bouaziz, Mounir; Turki, Olfa; Sellami, Walid; Vidal, Gabriela; Centeno, Pablo; Oscar Acevedo, José; Mabel Lopez, Patricia; Fernández, Rubén; Segura, Matías; Nuccetelli Pablo Montefiore, Yanina; Arias, Mario; Felipe Reyes, Luis; Felipe Reyes, Luis; A Ñamendys-Silva, Silvio; A Ñamendys-Silva, Silvio; P Romero-Gonzalez, Juan; Hermosillo, Mariana; Alejandro Castillo, Roberto; Nicolás Pantoja Leal, Jesús; Garcia Aguilar, Candy; Ocotlan Gonzalez Herrera, Mara; Vladimir Espinoza Villafuerte, Missael; Lomeli-Teran, Manuel; G Dominguez-Cherit, Jose; A Ñamendys-Silva, Adrian Davalos-AlvarezSilvio; Sánchez-Hurtado, Luis; Tejeda-Huezo, Brigitte; R Perez-Nieto Ernesto Deloya Tomas, Orlando; De Bus, Liesbet; De Waele, Jan; Francoisliesbet De Bus, Guy; De Waele, Jan; Hollevoet, Isabelle; Denys, Wouter; Bourgeois, Marc; M Vanderhaeghen, Sofie F; Mesland, Jean-Baptiste; Henin, Pierre; Haentjens, Lionel; Biston Cindérella Noel, Patrick; Layos Benoît Misset, Nathalie; De Schryver Nicolas Serck, Nicolas; Wittebole Elisabeth De Waele, Xavier; Opdenacker, Godelive; Kovacevic, Pedja; Kovacevic, Pedja; Zlojutro, Biljana; Filipovic-Grcic, Ina; Custovic, Aida; Filipovic-Grcic, Ina; Radonic, Radovan; Vujaklija Brajkovic, Ana; Persec, Jasminka; Sakan, Sanja; Nikolic, Mario; Lasic, Hrvoje; Leone, Marc; Timsit, Jean-François; Ruppe, Etienne; Ruckly, Stephane; Montravers, Philippe; Leone, Marc; Arbelot, Charlotte; N Zappella, Jean-François Timsit; Montravers, P; Dulac, Thierry; Castanera, Jérémy; Auchabie Anthony Le Meur, Johann; Marchalot, A; Beuzelin, M; Massri Charlotte Guesdon, Alexandre; Escudier, Etienne; Mateu Jérémy Rosman, Philippe; Leroy Serge Alfandari, Olivier; Nica, Alexandru; Souweine Elisabeth Coupez, Bertrand; Duburcq Eric Kipnis, Thibault; Bortolotti, Perrine; Le Souhaitier, Mathieu; Mira, Jean-Paul; Garcon Matthieu Duprey, Pierre; Thyrault Rémi Paulet, Martial; Philippart Marc Tran, François; Bruel, Cédric; Weiss, Emmanuel; Janny, Sylvie; Foucrier, Arnaud; Perrigault, Pierre-François; Djanikian, Flora; Barbier, François; Gainnier Jérémy Bourenne, Marc; Louis, Guillaume; Smonig, Roland; Argaud Thomas Baudry, Laurent; Mekonted Dessap Keyvan Razazi, Armand; Kalfon Gaëtan Badre, Pierre; Larcher, Romaric; Lefrant, Jean-Yves; Roger, Claire; Sarton Stein Silva, Benjamine; Demeret Loïc Le Guennec, Sophie; Siami, Shidasp; Aparicio, Christelle; Voiriot, Guillaume; Fartoukh, Muriel; Dahyot-Fizelier, Claire; Imzi, Nadia; Klouche, Kada; Bracht, Hendrik; Bracht, Hendrik; Hoheisen, Sandra; Bloos, Frank; Thomas-Rueddel, Daniel; Petros, Sirak; Pasieka, Bastian; Dubler Karsten Schmidt, Simon; Gottschalk, Antje; Wempe, Carola; Lepper, Philippe; Metz, Carlos; Viderman, Dmitriy; Viderman, Dmitriy; Umbetzhanov, Yerlan; Mugazov, Miras; Bazhykayeva, Yelena; Kaligozhin, Zhannur; Babashev, Baurzhan; Merenkov, Yevgeniy; Temirov, Talgat; Arvaniti, Kostoula; Arvaniti, Kostoula; Smyrniotis, Dimitrios; Psallida, Vasiliki; Fildisis, Georgios; Soulountsi, Vasiliki; Kaimakamis, Evangelos; Iasonidou, Cristina; Papoti, Sofia; Renta, Foteini; Vasileiou, Maria; Romanou, Vasiliki; Koutsoukou, Vasiliki; Kristina Matei, Mariana; Moldovan, Leora; Karaiskos, Ilias; Paskalis, Harry; Marmanidou, Kyriaki; Papanikolaou, M; Kampolis, C; Oikonomou, Marina; Kogkopoulos, Evangelos; Nikolaou, Charikleia; Sakkalis, Anastasios; Chatzis Maria Georgopoulou, Marinos; Efthymiou Vasiliki Chantziara, Anna; Sakagianni Zoi Athanasa, Aikaterini; Papageorgiou, Eirini; Ali, Fadi; Dimopoulos, Georges; Panagiota Almiroudi, Mariota; Malliotakis, Polychronis; Marouli, Diamantina; Theodorou, Vasiliki; Retselas, Ioannis; Kouroulas, Vasilios; Papathanakos, Georgios; Bassetti, Matteo; Giacobbe, Daniele; Montrucchio, Giorgia; Sales, Gabriele; De Pascale, Gennaro; Maria Montini, Luca; Carelli, Simone; Vargas, Joel; Di Gravio, Valentina; Roberto Giacobbe, Daniele; Gratarola, Angelo; Porcile, Elisa; Mirabella, Michele; Daroui, Ivan; Lodi, Giovanni; Zuccaro, Francesco; Grazia Schlevenin, Maria; Pelosi, Paolo; Battaglini, Denise; Cortegiani, Andrea; Ippolito, Mariachiara; Bellina, Davide; Di Guardo, Andrea; Pelagalli, Lorella; Covotta, Marco; Rocco, Monica; Fiorelli, Silvia; Cotoia, Antonella; Chiara Rizzo, Anna; Mikstacki, Adam; Mikstacki, Adam; Tamowicz, Barbara; Kaptur Komorowska, Irmina; Szczesniak, Anna; Bojko, Jozef; Kotkowska, Anna; Walczak-Wieteska, Paulina; Wasowska, Dominika; Nowakowski, Tomasz; Broda, Hanna; Peichota, Mariusz; Pietraszek-Grzywaczewska, Iwona; Martin-Loeches, Ignacio; Martin-Loeches, Ignacio; Bisanti, Alessandra; Póvoa, Pedro; Cartoze Tiago Pereira, Nuno; Guimarães Madalena Alves, Nádia; Josefina Pinheiro Ana Rios Marquespinto, Ana; Krystopchuk Ana Teresa, Andriy; De Almeida, Jose; Manuel Pereira De Figueiredo, António; Botelho, Isabel; Duarte, Tiago; Costa, Vasco; Pedro Cunha, Rui; Molinos Tito Da Costa, Elena; Ledo Joana Queiró, Sara; Pascoalinho, Dulce; Nunes, Cristina; Pedro Moura, José; Pereira, Énio; Carvalho Mendes, António; Valeanu, Liana; C Iliescu, C; Valeanu, Liana; Bubenek-Turconi, Serban; Marina Grintescu, Ioana; Cobilinschi, Cristian; C Iliescu, C; Carmen Filipescu, Daniela; Elena Predoi, Cornelia; Tomescu, Dana; Popescu, Mihai; Marcu, Alexandra; Grigoras, Ioana; Lungu, Olguta; Gritsan, Alexey; Anderzhanova, Anastasia; Meleshkina, Yulia; Magomedov, Marat; Zubareva, Nadezhda; Tribulev, Maksim; Gaigolnik, Denis; Eremenko, Aleksandr; Vistovskaya, Natala; Chukina, Maria; Belskiy, Vladislav; Furman, Mikhail; Ferrer Rocca, Ricard; Ferrer Rocca, Ricard; Martinez, Maria; Casares, Vanessa; Mellado Artigas, Ricard; Vera, Paula; Flores, Matias; Amador Amerigo, Joaquin; Pilar Gracia Arnillas, Maria; Munoz Bermudez, Rosana; Armestar, Fernando; Catalan, Beatriz; Roig, Regina; Raguer, Laura; Dolores Quesada, María; Diaz Santos, Emilio; Gomà, Gemma; Ubeda, Alejandro; Forcelledo Espina, Lorena; Garcia Prieto, Emilio; Mj Asensio, Dra; M Rodriguez, Dra; Maseda, Emilio; Suarez De La Rica, Alejandro; Ignacio Ayestaran, J; Novo, Mariana; Angel Blasco-Navalpotro, Miguel; Orejas Gallego, Alberto; Sjovall, Fredrik; Sjövall, Fredrik; Spahic, Dzana; Johan Svensson, Carl; Haney, Michael; Edin, Alicia; Åkerlund, Joyce; De Geer, Lina; Prazak, Josef; Buetti, Niccolò; Prazak, Josef; Jakob, Stephan; L Pagani, J; Abed-Maillard, S; Akova, Murat; Tarık Aslan, Abdullah; Akova, Murat; Tarik Aslan, Abdullah; Timuroglu, Arif; Kocagoz, Sesin; Kusoglu, Hulya; Mehtap, Selcuk; Ceyhun, Solakoğlu; Defne Altintas, Neriman; Talan, Leyla; Kayaaslan, Bircan; Kaya Kalem, Ayşe; Kurt, Ibrahim; Telli, Murat; Ozturk, Barcin; Erol, Çiğdem; Kubra Dindar Demiray, Emine; Çolak, Sait; Akbas, Türkay; Gundogan, Kursat; Sari, Ali; Agalar, Canan; Çolak, Onur; Baykam, Nurcan; Akdogan, Ozlem; Yilmaz, Mesut; Tunay, Burcu; Cakmak, Rumeysa; Saltoglu, Nese; Karaali, Ridvan; Koksal, Iftihar; Aksoy, Firdevs; Eroglu, Ahmet; Tolga Saracoglu, Kemal; Bilir, Yeliz; Ersoz, Gulden; Evik, Guliz; Sungurtekin, Hulya; Ozgen, Cansu; Erdoğan, Cem; Gürbüz, Yunus; Altin, Nilgün; Bayindir, Yasar; Ersoy, Yasemin; Goksu, Senay; Batirel, Ayse; Cagan Aktas, Sabahat; Conway Morris, Andrew; Conway Morris, Andrew; Routledge, Matthew; Conway Morris, Andrew; Ercole, Ari; Antcliffe, David; Rojo, Roceld; Tizard, Kate; Faulkner, Maria; Cowton, Amanda; Kent, Melanie; Raj, Ashok; Zormpa, Artemis; Tinaslanidis, George; Khade, Reena; Torlinski, Tomasz; Mulhi, Randeep; Goyal, Shraddha; Bajaj, Manan; Soltan, Marina; Yonan, Aimee; Dolan, Rachael; Johnson, Aimee; Macfie, Caroline; Lennard, James; Templeton, Maie; Sousa Arias, Sonia; Franke, Uwe; Hugill, Keith; Angell, Hollie; J Parcell, Benjamin; Cobb, Katherine; Cole, Stephen; Smith, Tim; Graham, Clive; Cerman, Jaroslav; Keegan, Allison; Ritzema, Jenny; Sanderson, Amanda; Roshdy, Ashraf; Szakmany, Tamas; Baumer, Tom; Longbottom, Rebecca; Hall, Daniel; Tatham, Kate; Loftus, S; Husain, A; Black, E; Jhanji, S; Baikady, Rrao; Mcguigan, Peter; Mckee, Rachel; Kannan, Santhana; Antrolikar, Supriya; Marsden, Nicholas; Della Torre, Valentina; Banach, Dorota; Zaki, Ahmed; Jackson, Matthew; Chikungwa, Moses; Attwood, Ben; Patel, Jamie; E Tilley, Rebecca; K Humphreys, Sally; Jean Renaud, Paul; Sokhan, Anton; Burma, Yaroslava; Sligl, Wendy; Sligl, Wendy; J Kutsogiannis, Demetrios; Sligl, Wendy; Rabbani, Raihan; Rabbani, Raihan; Mahmud Redwanul Huq, Shihan; Hasan, Rajib; Motiul Islam, Mohammad; Gurjar, Mohan; Gurjar, Mohan; Baronia, Arvind; Kothari, Nikhil; Sharma, Ankur; Karmakar, Saurabh; Sharma, Priya; Nimbolkar, Janardan; Samdani, Pratit; Vaidyanathan, R; Ahmedi Rubina, Noor; Jain, Nikhilesh; Pahuja, Madhumati; Singh, Ritu; Shekhar, Saurav; Nabeel Muzaffar, Syed; Ozair, Ahmad; Sarwar Siddiqui, Suhail; Bose, Payel; Datta, Avijatri; Rathod, Darshana; Patel, Mayur; K Renuka, M; K Baby, Sailaja; Dsilva, Carol; Chandran, Jagadish; Ghosh, Pralay; Mukherjee, Sudipta; Sheshala, Kaladhar; Chandra Misra, Krushna; O Adekola, Oyebola; Yusuf Yakubu, Saidu; Mgbosoro Ugwu, Euphemia; Olatosi, John; Desalu, Ibironke; Asiyanbi, Gabriel; Oladimeji, Motunrayo; Idowu, Olusola; Adeola, Fowotade; Mer, Mervyn; Mer, Mervyn; Mc Cree, Melanie; El Sanousi, Bashir; Adil Ali Karar, Ali; Saidahmed, Elfayadh; S Hamid, Hytham K. - In: INTENSIVE CARE MEDICINE. - ISSN 1432-1238. - 51:3(2025), pp. 518-528. [10.1007/s00134-025-07857-6]

Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database

Monica Rocco;Silvia Fiorelli;
2025

Abstract

INTRODUCTION: Hospital-acquired bloodstream infections (HA-BSIs) are severe and require antibiotic therapy. In non-complicated BSIs, shortened therapy reduces side effects without compromising efficacy. The impact of shortened antibiotic therapy in HA-BSI critically ill patients without indication of prolonged therapy requires further evaluation. METHODS: Using the international prospective EUROBACT-2 cohort, we compared shortened (7-10 days) versus long (14-21 days) treatment durations in ICU patients eligible for shortened therapy. Patients without antibiotic therapy within 3 days after HA-BSI occurrence or requiring prolonged therapy (due to infection source, microorganism, or clinical deterioration) were excluded. Treatment failure, defined as death, persistent infection, or subsequent infectious complications by Day 28, was assessed using an inverse-probability of treatment weighted (IPTW) logistic regression. RESULTS: Among 2600 patients, 550 were eligible for shortened treatment, 213 received short, and 337 received long treatment. The most common infection source was intravascular catheters (33%), most common microorganisms were Enterobacterales (39%). Patients with long treatment were more frequently infected with Staphylococcus aureus (11% vs. 5.6%, p = 0.025) or difficult-to-treat microorganisms (23% vs. 7%, p < 0.001), and received more commonly combination therapy (46% vs. 30%, p < 0.001). Short treatment was associated with reduced 28-day treatment failure (OR 0.64, 95% CI 0.44-0.93, p = 0.019), mainly due to reduction in subsequent infectious complications (OR 0.58, 95% CI 0.37-0.91, p = 0.018). Mortality (OR 0.92 [95% CI 0.59, 1.43], p = 0.7) and persistent infection rates (OR 0.47 [95% CI 0.17, 1.14], p = 0.12) were similar. CONCLUSIONS: In selected ICU patients with HA-BSI, shortened antibiotic treatment might be considered. Eurobact2 was a prospective international cohort study, registered in ClinicalTrials.org (NCT03937245).
2025
Antibiotic therapy duration; Critically ill; Hospital-acquired bloodstream infection
01 Pubblicazione su rivista::01a Articolo in rivista
Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database / Lena, Gajdos; Niccolo, Buetti; Alexis, Tabah; Stephane, Ruckly; Murat, Akova; Frederik, Sjöval; Kostoula, Arvaniti; Jan, De Waele; Hendrik, Bracht; Francois, Barbier; Timsit, ; Alexis Tabah, Jean-François; Lipman, Jeffrey; Tabah, Alexis; Pollock, Hamish; Margetts, Ben; Udy, Andrew; Young, Meredith; Bhadange, Neeraj; Tyler, Steven; Ledtischke, Anne; Finnis, Mackenzie; Ledtischke, Anne; Finnis, Mackenzie; Dwivedi, Jyotsna; Saxena, Manoj; Biradar, Vishwanath; Soar, Natalie; Sarode, Vineet; Brewster, David; Regli, Adrian; Weeda, Elizabeth; Ahmed, Samiul; Fourie, Cheryl; Laupland, Kevin; Ramanan, Mahesh; Walsham, James; Meyer, Jason; Litton, Edward; Maria Palermo, Anna; Yap, Timothy; Eroglu, Ege; George Attokaran, Antony; Jaramillo, C'Havala; Mk Nafees, Khalid; Mahmood Khan Nafees, Khalid; Aqilah Haji Abd Rashid, Nurhikmahtul; Adi Muhamad Ibnu Walid, Haji; Mon, Tomas; Dhakshina Moorthi, P; Sudhirchandra, Shah; Damodar Sridharan, Dhadappa; Haibo, Qiu; Xie, Jianfeng; Haibo, Qiu; Jianfeng, Xie; Wei-Hua, Lu; Zhen, Wang; Qian, Chuanyun; Luo, Jili; Chen, Xiaomei; Wang, Hao; Zhao, Peng; Zhao, Juan; Wusi, Qiu; Mingmin, Chen; Xu, Lei; Yin, Chengfen; Wang, Ruilan; Wang, Jinfeng; Yin, Yongjie; Zhang, Min; Ye, Jilu; Hu, Chungfang; Zhou, Suming; Huang, Min; Yan, Jing; Wang, Yan; Qin, Bingyu; Ye, Ling; Weifeng, Xie; Peije, Li; Geng, Nan; Ling, Lowell; Ling, Lowell; Hayashi, Yoshiro; Hayashi, Yoshiro; Karumai, Toshiyuki; Yamasaki, Masaki; Hashimoto, Satoru; Hosokawa, Koji; Makino, Jun; Matsuyoshi, Takeo; Kuriyama, Akira; Shigemitsu, Hidenobu; Mishima, Yuka; Nagashima, Michio; Yoshida, Hideki; Fujitani, Shigeki; Omori, Koichiro; Rinka, Hiroshi; Saito, Hiroki; Atobe, Kaori; Kato, Hideaki; Takaki, Shunsuke; Sulaiman, Helmi; Shahnaz Hasan, M; Fadhil Hadi Jamaluddin, Muhamad; See Pheng, Lee; Visvalingam, Sheshendrasurian; Thing Liew, Mun; Ling Danny Wong, Siong; Khang Fong, Kean; Bt Abdul Rahman, Hamizah; Md Noor, Zuraini; Kok Tong, Lee; Hamid Azman, Abd; Zulfakar Mazlan, Mohd; Ali, Saedah; Mark Hernandez, Aaron; Abello, Anton; Jeon, Kyeongman; Jeon, Kyeongman; Lee, Sang-Min; Park, Sunghoon; Yong Park, Seung; Yoon Lim, Sung; Lay Hoon Kwa, Andrea; Yuan Goh, Qing; Yuan Goh, Qing; Yi Ng, Shin; An Lie, Sui; Lay Hoon Kwa, Andrea; Junyang Goh, Ken; Yunkai Li, Andrew; Yu Ming Ong, Caroline; Yan Lim, Jia; Lishan Quah, Jessica; Ng, Kangqi; Yu-Chang Yeh, Tony; Chang Yeh, Yu; Chou, Nai-Kuan; Cia, Cong-Tat; Hu, Ting-Yu; Kuo, Li-Kuo; Ku, Shih-Chi; Wongsurakiat, Phunsup; Wongsurakiat, Phunsup; Apichatbutr, Yutthana; Chiewroongro, Supattra; Alsisi, Adel; Nadeem, Rashid; El Houfi, Ashraf; Alsisi, Adel; Alsisi, Adel; Elhadidy, Amr; Barsoum, Mina; Osman, Nermin; Mostafa, Tarek; Elbahnasawy, Mohamed; Saber, Ahmed; Aldhalia, Amer; Elmandouh, Omar; Elsayed, Ahmed; A Elbadawy, Merihan; K Awad, Ahmed; M Hemead, Hanan; Zand, Farid; Zand, Farid; Ouhadian, Maryam; Hamid Borsi, Seyed; Mehraban, Zahra; Kashipazha, Davood; Ahmadi, Fatemeh; Savaie, Mohsen; Soltani, Farhad; Rashidi, Mahboobeh; Baghbanian, Reza; Javaherforoosh, Fatemeh; Amiri, Fereshteh; Kiani, Arash; Amin Zargar, Mohammad; Mahmoodpoor, Ata; Aalinezhad, Fatemeh; Dabiri, Gholamreza; Sabetian, Golnar; Sarshad, Hakimeh; Masjedi, Mansoor; Tajvidi, Ramin; Mohammad Nasirodin Tabatabaei, Seyed; Khudhur Ahmed, Abdullah; Singer, Pierre; Singer, Pierre; Kagan, Ilya; Rigler, Merav; Belman, Daniel; Levin, Phillip; Harara, Belal; Diab, Adei; Abillama, Fayez; Abilama, Fayez; Ibrahim, Rebecca; Fares, Aya; Elhadi, Muhammed; Buimsaedah, Ahmad; Gamra, Marwa; Aqeelah, Ahmed; Mohammed Aliali, Almajdoub; Gaber Sadik Homaidan, Ahmed; Almiqlash, Bushray; Bilkhayr, Hala; Bouhuwaish, Ahmad; Sa Taher, Ahmed; Abdulwahed, Eman; A Abousnina, Fathi; Khaled Hdada, Aisha; Jobran, Rania; Ben Hasan, Hayat; Shaban Ben Hasan, Rabab; Abidi, Khalid; Serghini, Issam; Seddiki, Rachid; Boukatta, Brahim; Kanjaa, Nabil; Mouhssine, Doumiri; Ahmed Wajdi, Maazouzi; Dendane, Tarek; Ali Zeggwagh, Amine; Housni, Brahim; Younes, Oujidi; Hachimi, Abdelhamid; Ghannam, A; Belkhadir, Z; Amro, Sarah; Abu Jayyab, Mustafa; Aithssain, Ali; Ait Hssain, Ali; Elbuzidi, Abdurahaman; Karic, Edin; Lance, Marcus; Nissar, Shaikh; Sallam, Hend; Elrabi, Omar; A Almekhlafi, Ghaleb; Awad, Maher; Aljabbary, Ahmed; Karam Chaaban, Mohammad; Abu-Sayf, Natalia; Al-Jadaan, Mohammad; Bakr, Lubna; Bouaziz, Mounir; Bouaziz, Mounir; Turki, Olfa; Sellami, Walid; Vidal, Gabriela; Centeno, Pablo; Oscar Acevedo, José; Mabel Lopez, Patricia; Fernández, Rubén; Segura, Matías; Nuccetelli Pablo Montefiore, Yanina; Arias, Mario; Felipe Reyes, Luis; Felipe Reyes, Luis; A Ñamendys-Silva, Silvio; A Ñamendys-Silva, Silvio; P Romero-Gonzalez, Juan; Hermosillo, Mariana; Alejandro Castillo, Roberto; Nicolás Pantoja Leal, Jesús; Garcia Aguilar, Candy; Ocotlan Gonzalez Herrera, Mara; Vladimir Espinoza Villafuerte, Missael; Lomeli-Teran, Manuel; G Dominguez-Cherit, Jose; A Ñamendys-Silva, Adrian Davalos-AlvarezSilvio; Sánchez-Hurtado, Luis; Tejeda-Huezo, Brigitte; R Perez-Nieto Ernesto Deloya Tomas, Orlando; De Bus, Liesbet; De Waele, Jan; Francoisliesbet De Bus, Guy; De Waele, Jan; Hollevoet, Isabelle; Denys, Wouter; Bourgeois, Marc; M Vanderhaeghen, Sofie F; Mesland, Jean-Baptiste; Henin, Pierre; Haentjens, Lionel; Biston Cindérella Noel, Patrick; Layos Benoît Misset, Nathalie; De Schryver Nicolas Serck, Nicolas; Wittebole Elisabeth De Waele, Xavier; Opdenacker, Godelive; Kovacevic, Pedja; Kovacevic, Pedja; Zlojutro, Biljana; Filipovic-Grcic, Ina; Custovic, Aida; Filipovic-Grcic, Ina; Radonic, Radovan; Vujaklija Brajkovic, Ana; Persec, Jasminka; Sakan, Sanja; Nikolic, Mario; Lasic, Hrvoje; Leone, Marc; Timsit, Jean-François; Ruppe, Etienne; Ruckly, Stephane; Montravers, Philippe; Leone, Marc; Arbelot, Charlotte; N Zappella, Jean-François Timsit; Montravers, P; Dulac, Thierry; Castanera, Jérémy; Auchabie Anthony Le Meur, Johann; Marchalot, A; Beuzelin, M; Massri Charlotte Guesdon, Alexandre; Escudier, Etienne; Mateu Jérémy Rosman, Philippe; Leroy Serge Alfandari, Olivier; Nica, Alexandru; Souweine Elisabeth Coupez, Bertrand; Duburcq Eric Kipnis, Thibault; Bortolotti, Perrine; Le Souhaitier, Mathieu; Mira, Jean-Paul; Garcon Matthieu Duprey, Pierre; Thyrault Rémi Paulet, Martial; Philippart Marc Tran, François; Bruel, Cédric; Weiss, Emmanuel; Janny, Sylvie; Foucrier, Arnaud; Perrigault, Pierre-François; Djanikian, Flora; Barbier, François; Gainnier Jérémy Bourenne, Marc; Louis, Guillaume; Smonig, Roland; Argaud Thomas Baudry, Laurent; Mekonted Dessap Keyvan Razazi, Armand; Kalfon Gaëtan Badre, Pierre; Larcher, Romaric; Lefrant, Jean-Yves; Roger, Claire; Sarton Stein Silva, Benjamine; Demeret Loïc Le Guennec, Sophie; Siami, Shidasp; Aparicio, Christelle; Voiriot, Guillaume; Fartoukh, Muriel; Dahyot-Fizelier, Claire; Imzi, Nadia; Klouche, Kada; Bracht, Hendrik; Bracht, Hendrik; Hoheisen, Sandra; Bloos, Frank; Thomas-Rueddel, Daniel; Petros, Sirak; Pasieka, Bastian; Dubler Karsten Schmidt, Simon; Gottschalk, Antje; Wempe, Carola; Lepper, Philippe; Metz, Carlos; Viderman, Dmitriy; Viderman, Dmitriy; Umbetzhanov, Yerlan; Mugazov, Miras; Bazhykayeva, Yelena; Kaligozhin, Zhannur; Babashev, Baurzhan; Merenkov, Yevgeniy; Temirov, Talgat; Arvaniti, Kostoula; Arvaniti, Kostoula; Smyrniotis, Dimitrios; Psallida, Vasiliki; Fildisis, Georgios; Soulountsi, Vasiliki; Kaimakamis, Evangelos; Iasonidou, Cristina; Papoti, Sofia; Renta, Foteini; Vasileiou, Maria; Romanou, Vasiliki; Koutsoukou, Vasiliki; Kristina Matei, Mariana; Moldovan, Leora; Karaiskos, Ilias; Paskalis, Harry; Marmanidou, Kyriaki; Papanikolaou, M; Kampolis, C; Oikonomou, Marina; Kogkopoulos, Evangelos; Nikolaou, Charikleia; Sakkalis, Anastasios; Chatzis Maria Georgopoulou, Marinos; Efthymiou Vasiliki Chantziara, Anna; Sakagianni Zoi Athanasa, Aikaterini; Papageorgiou, Eirini; Ali, Fadi; Dimopoulos, Georges; Panagiota Almiroudi, Mariota; Malliotakis, Polychronis; Marouli, Diamantina; Theodorou, Vasiliki; Retselas, Ioannis; Kouroulas, Vasilios; Papathanakos, Georgios; Bassetti, Matteo; Giacobbe, Daniele; Montrucchio, Giorgia; Sales, Gabriele; De Pascale, Gennaro; Maria Montini, Luca; Carelli, Simone; Vargas, Joel; Di Gravio, Valentina; Roberto Giacobbe, Daniele; Gratarola, Angelo; Porcile, Elisa; Mirabella, Michele; Daroui, Ivan; Lodi, Giovanni; Zuccaro, Francesco; Grazia Schlevenin, Maria; Pelosi, Paolo; Battaglini, Denise; Cortegiani, Andrea; Ippolito, Mariachiara; Bellina, Davide; Di Guardo, Andrea; Pelagalli, Lorella; Covotta, Marco; Rocco, Monica; Fiorelli, Silvia; Cotoia, Antonella; Chiara Rizzo, Anna; Mikstacki, Adam; Mikstacki, Adam; Tamowicz, Barbara; Kaptur Komorowska, Irmina; Szczesniak, Anna; Bojko, Jozef; Kotkowska, Anna; Walczak-Wieteska, Paulina; Wasowska, Dominika; Nowakowski, Tomasz; Broda, Hanna; Peichota, Mariusz; Pietraszek-Grzywaczewska, Iwona; Martin-Loeches, Ignacio; Martin-Loeches, Ignacio; Bisanti, Alessandra; Póvoa, Pedro; Cartoze Tiago Pereira, Nuno; Guimarães Madalena Alves, Nádia; Josefina Pinheiro Ana Rios Marquespinto, Ana; Krystopchuk Ana Teresa, Andriy; De Almeida, Jose; Manuel Pereira De Figueiredo, António; Botelho, Isabel; Duarte, Tiago; Costa, Vasco; Pedro Cunha, Rui; Molinos Tito Da Costa, Elena; Ledo Joana Queiró, Sara; Pascoalinho, Dulce; Nunes, Cristina; Pedro Moura, José; Pereira, Énio; Carvalho Mendes, António; Valeanu, Liana; C Iliescu, C; Valeanu, Liana; Bubenek-Turconi, Serban; Marina Grintescu, Ioana; Cobilinschi, Cristian; C Iliescu, C; Carmen Filipescu, Daniela; Elena Predoi, Cornelia; Tomescu, Dana; Popescu, Mihai; Marcu, Alexandra; Grigoras, Ioana; Lungu, Olguta; Gritsan, Alexey; Anderzhanova, Anastasia; Meleshkina, Yulia; Magomedov, Marat; Zubareva, Nadezhda; Tribulev, Maksim; Gaigolnik, Denis; Eremenko, Aleksandr; Vistovskaya, Natala; Chukina, Maria; Belskiy, Vladislav; Furman, Mikhail; Ferrer Rocca, Ricard; Ferrer Rocca, Ricard; Martinez, Maria; Casares, Vanessa; Mellado Artigas, Ricard; Vera, Paula; Flores, Matias; Amador Amerigo, Joaquin; Pilar Gracia Arnillas, Maria; Munoz Bermudez, Rosana; Armestar, Fernando; Catalan, Beatriz; Roig, Regina; Raguer, Laura; Dolores Quesada, María; Diaz Santos, Emilio; Gomà, Gemma; Ubeda, Alejandro; Forcelledo Espina, Lorena; Garcia Prieto, Emilio; Mj Asensio, Dra; M Rodriguez, Dra; Maseda, Emilio; Suarez De La Rica, Alejandro; Ignacio Ayestaran, J; Novo, Mariana; Angel Blasco-Navalpotro, Miguel; Orejas Gallego, Alberto; Sjovall, Fredrik; Sjövall, Fredrik; Spahic, Dzana; Johan Svensson, Carl; Haney, Michael; Edin, Alicia; Åkerlund, Joyce; De Geer, Lina; Prazak, Josef; Buetti, Niccolò; Prazak, Josef; Jakob, Stephan; L Pagani, J; Abed-Maillard, S; Akova, Murat; Tarık Aslan, Abdullah; Akova, Murat; Tarik Aslan, Abdullah; Timuroglu, Arif; Kocagoz, Sesin; Kusoglu, Hulya; Mehtap, Selcuk; Ceyhun, Solakoğlu; Defne Altintas, Neriman; Talan, Leyla; Kayaaslan, Bircan; Kaya Kalem, Ayşe; Kurt, Ibrahim; Telli, Murat; Ozturk, Barcin; Erol, Çiğdem; Kubra Dindar Demiray, Emine; Çolak, Sait; Akbas, Türkay; Gundogan, Kursat; Sari, Ali; Agalar, Canan; Çolak, Onur; Baykam, Nurcan; Akdogan, Ozlem; Yilmaz, Mesut; Tunay, Burcu; Cakmak, Rumeysa; Saltoglu, Nese; Karaali, Ridvan; Koksal, Iftihar; Aksoy, Firdevs; Eroglu, Ahmet; Tolga Saracoglu, Kemal; Bilir, Yeliz; Ersoz, Gulden; Evik, Guliz; Sungurtekin, Hulya; Ozgen, Cansu; Erdoğan, Cem; Gürbüz, Yunus; Altin, Nilgün; Bayindir, Yasar; Ersoy, Yasemin; Goksu, Senay; Batirel, Ayse; Cagan Aktas, Sabahat; Conway Morris, Andrew; Conway Morris, Andrew; Routledge, Matthew; Conway Morris, Andrew; Ercole, Ari; Antcliffe, David; Rojo, Roceld; Tizard, Kate; Faulkner, Maria; Cowton, Amanda; Kent, Melanie; Raj, Ashok; Zormpa, Artemis; Tinaslanidis, George; Khade, Reena; Torlinski, Tomasz; Mulhi, Randeep; Goyal, Shraddha; Bajaj, Manan; Soltan, Marina; Yonan, Aimee; Dolan, Rachael; Johnson, Aimee; Macfie, Caroline; Lennard, James; Templeton, Maie; Sousa Arias, Sonia; Franke, Uwe; Hugill, Keith; Angell, Hollie; J Parcell, Benjamin; Cobb, Katherine; Cole, Stephen; Smith, Tim; Graham, Clive; Cerman, Jaroslav; Keegan, Allison; Ritzema, Jenny; Sanderson, Amanda; Roshdy, Ashraf; Szakmany, Tamas; Baumer, Tom; Longbottom, Rebecca; Hall, Daniel; Tatham, Kate; Loftus, S; Husain, A; Black, E; Jhanji, S; Baikady, Rrao; Mcguigan, Peter; Mckee, Rachel; Kannan, Santhana; Antrolikar, Supriya; Marsden, Nicholas; Della Torre, Valentina; Banach, Dorota; Zaki, Ahmed; Jackson, Matthew; Chikungwa, Moses; Attwood, Ben; Patel, Jamie; E Tilley, Rebecca; K Humphreys, Sally; Jean Renaud, Paul; Sokhan, Anton; Burma, Yaroslava; Sligl, Wendy; Sligl, Wendy; J Kutsogiannis, Demetrios; Sligl, Wendy; Rabbani, Raihan; Rabbani, Raihan; Mahmud Redwanul Huq, Shihan; Hasan, Rajib; Motiul Islam, Mohammad; Gurjar, Mohan; Gurjar, Mohan; Baronia, Arvind; Kothari, Nikhil; Sharma, Ankur; Karmakar, Saurabh; Sharma, Priya; Nimbolkar, Janardan; Samdani, Pratit; Vaidyanathan, R; Ahmedi Rubina, Noor; Jain, Nikhilesh; Pahuja, Madhumati; Singh, Ritu; Shekhar, Saurav; Nabeel Muzaffar, Syed; Ozair, Ahmad; Sarwar Siddiqui, Suhail; Bose, Payel; Datta, Avijatri; Rathod, Darshana; Patel, Mayur; K Renuka, M; K Baby, Sailaja; Dsilva, Carol; Chandran, Jagadish; Ghosh, Pralay; Mukherjee, Sudipta; Sheshala, Kaladhar; Chandra Misra, Krushna; O Adekola, Oyebola; Yusuf Yakubu, Saidu; Mgbosoro Ugwu, Euphemia; Olatosi, John; Desalu, Ibironke; Asiyanbi, Gabriel; Oladimeji, Motunrayo; Idowu, Olusola; Adeola, Fowotade; Mer, Mervyn; Mer, Mervyn; Mc Cree, Melanie; El Sanousi, Bashir; Adil Ali Karar, Ali; Saidahmed, Elfayadh; S Hamid, Hytham K. - In: INTENSIVE CARE MEDICINE. - ISSN 1432-1238. - 51:3(2025), pp. 518-528. [10.1007/s00134-025-07857-6]
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