Association of TP53 Arg72Pro (rs1042522) Polymorphism with Pancreatic Cancer Risk in a Patient Cohort

Pancreatic cancer is one of the most deadly forms of cancer because it is often diagnosed too late, when treatments are less effective. Currently, there is no practical way to screen individuals who are at risk but have no symptoms. In this study, we describe a specific genetic variation in a gene called TP53, which is known to play a role in many types of cancer. We found that this variation appears to be more common in people with pancreatic cancer than in the general population. This suggests that individuals carrying this variation may have a higher risk of developing the disease. These findings may help open a new line of research aimed at identifying high-risk populations.