IMAGING UPDATE OCT SPOTLIGHT: CHARACTERIZING GA DEVELOPMENT AND PROGRESSION

Several biomarkers have been implicated in geographic atrophy (GA) prediction and prognosis, including reticular pseudodrusen, hyperreflective foci, thickness loss of specific retinal bands, drusen volume, and hyporeflective cores within drusen. However, current biomarkers do not fully account for the high variability observed in the progression of atrophic lesions. The authors have developed a predictive model based on the phenotypic elementary lesions of intermediate AMD associated with GA.