Cysteine sulfinate (CSA) and hypotaurine are recognized as key intermediates in the metabolic pathway leading from cysteine to taurine. The oxidation of sulfinic group to the respective sulfonate is a crucial point for generation of taurine in mammalian tissues. The mechanism of sulfinic group oxidation could not be related to specific enzymatic activities. However, oxidizing agents, such as hydroxyl radical, photochemically generated singlet oxygen and peroxynitrite have been reported to accomplish such oxidation in good yield.
Effects of hypotaurine on carbonate radical anion and nitrogen dioxide radical generated by peroxidase activity of Cu,Zn-superoxide dismutase / Conrado, Alessia Baseggio; Pecci, Laura; Fontana, Mario. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 65:(2013), pp. S23-S24. [10.1016/j.freeradbiomed.2013.08.011]
Effects of hypotaurine on carbonate radical anion and nitrogen dioxide radical generated by peroxidase activity of Cu,Zn-superoxide dismutase
Conrado, Alessia Baseggio
Primo
;Fontana, Mario
2013
Abstract
Cysteine sulfinate (CSA) and hypotaurine are recognized as key intermediates in the metabolic pathway leading from cysteine to taurine. The oxidation of sulfinic group to the respective sulfonate is a crucial point for generation of taurine in mammalian tissues. The mechanism of sulfinic group oxidation could not be related to specific enzymatic activities. However, oxidizing agents, such as hydroxyl radical, photochemically generated singlet oxygen and peroxynitrite have been reported to accomplish such oxidation in good yield.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
