The commercially available and experimentally convenient (bp 65 °C) difluoromethyltrimethylsilane (TMSCHF2) is proposed as a valuable difluoromethylating transfer reagent for delivering the CHF2 moiety to various heteroatom-based electrophiles. Upon activation with an alkoxide, a conceptually intuitive nucleophilic displacement directly furnishes in high yields the bench-stable analogues.
Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF2 / Miele, M.; Castoldi, L.; Simeone, X.; Holzer, W.; Pace, V.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 58:38(2022), pp. 5761-5764. [10.1039/d2cc00886f]
Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF2
Pace V.
2022
Abstract
The commercially available and experimentally convenient (bp 65 °C) difluoromethyltrimethylsilane (TMSCHF2) is proposed as a valuable difluoromethylating transfer reagent for delivering the CHF2 moiety to various heteroatom-based electrophiles. Upon activation with an alkoxide, a conceptually intuitive nucleophilic displacement directly furnishes in high yields the bench-stable analogues.| File | Dimensione | Formato | |
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Miele_Straightforward_2022.pdf
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Miele_supplementary_Straightforward_2022.pdf
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