In this article, the quantitative determination of acetylsalicylic acid (ASA) contained in two of the most commercially available pharmaceutical formulations was performed using differential scanning calorimetry (DSC) after a thermoanalytical characterization and a preliminary test on compatibility of ASA with three of the most commonly considered excipients [cellulose (CE), starch (ST) and sodium saccharin (SS)]. Finally, the analytical results obtained were compared with those derived by titrimetry and two UV spectrophotometric methods: i.e. a 'direct method' and a method based on first-order derivative UV spectra.
Quantitative determination of acetylsalicylic acid in commercial drugs using DSC. Comparison with titration and UV spectrophotometric methods / Campanella, Luigi; Valentina, Micieli; Tomassetti, Mauro; VECCHIO CIPRIOTI, Stefano. - In: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. - ISSN 1388-6150. - STAMPA. - 102:1(2010), pp. 249-259. [10.1007/s10973-010-0724-x]
Quantitative determination of acetylsalicylic acid in commercial drugs using DSC. Comparison with titration and UV spectrophotometric methods
CAMPANELLA, Luigi;TOMASSETTI, Mauro;VECCHIO CIPRIOTI, Stefano
2010
Abstract
In this article, the quantitative determination of acetylsalicylic acid (ASA) contained in two of the most commercially available pharmaceutical formulations was performed using differential scanning calorimetry (DSC) after a thermoanalytical characterization and a preliminary test on compatibility of ASA with three of the most commonly considered excipients [cellulose (CE), starch (ST) and sodium saccharin (SS)]. Finally, the analytical results obtained were compared with those derived by titrimetry and two UV spectrophotometric methods: i.e. a 'direct method' and a method based on first-order derivative UV spectra.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
