a-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.
Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines / Malik, Monika; Senatore, Raffaele; Castiglione, Davide; Roller-Prado, Alexander; Pace, Vittorio. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 59:74(2023), pp. 11065-11068. [10.1039/d3cc03326k]
Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines
Pace, Vittorio
2023
Abstract
a-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.| File | Dimensione | Formato | |
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