Background: Prostate adenocarcinoma is the most common malignancy in men in Italy, with generally favorable survival rates when detected early. Despite multiple treatment options, disease recurrence remains a clinical challenge. Case Presentation: Reported the case of a 78-year-old male with recurrent prostate adenocarcinoma initially diagnosed in 2009 (PSA 29 ng/mL). The patient underwent treatment with Casodex followed by external beam radiotherapy (62 Gy in 2010). Subsequent follow-up revealed biochemical recurrence and multiple local recurrences confirmed on PET/CT imaging. Over the years, the patient received androgen deprivation therapy (Enantone), anti androgens (Casodex, Enzalutamide), and repeat imaging demonstrated progression with prostate and seminal vesicle involvement. Investigations: Serial PSA monitoring, multiparametric imaging (PET
Prostate Adenocarcinoma / Cirolla, Virginia Angela. - In: INTERNATIONAL JOURNAL OF CONTEMPORARY RESEARCH IN MULTIDISCIPLINARY. - ISSN 2583-7397. - 4:5(2025), pp. 1-11. [10.5281/zenodo.17048326]
Prostate Adenocarcinoma
VIRGINIA ANGELA CIROLLAPrimo
Writing – Review & Editing
2025
Abstract
Background: Prostate adenocarcinoma is the most common malignancy in men in Italy, with generally favorable survival rates when detected early. Despite multiple treatment options, disease recurrence remains a clinical challenge. Case Presentation: Reported the case of a 78-year-old male with recurrent prostate adenocarcinoma initially diagnosed in 2009 (PSA 29 ng/mL). The patient underwent treatment with Casodex followed by external beam radiotherapy (62 Gy in 2010). Subsequent follow-up revealed biochemical recurrence and multiple local recurrences confirmed on PET/CT imaging. Over the years, the patient received androgen deprivation therapy (Enantone), anti androgens (Casodex, Enzalutamide), and repeat imaging demonstrated progression with prostate and seminal vesicle involvement. Investigations: Serial PSA monitoring, multiparametric imaging (PETI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
