Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain. Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC. Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model. Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16–53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12–0.26; p = 0.43), -0.58 for LMR (95% CI -1.21–0.05; p = 0.06), and 0.01 (95% CI 0–0.01; p = 0.21) for PLR. Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis (Reviews in Endocrine and Metabolic Disorders, (2023), 24, 6, (1205-1216), 10.1007/s11154-023-09845-x) / Russo, Elena; Guizzardi, Mathilda; Canali, Luca; Gaino, Francesca; Costantino, Andrea; Mazziotti, Gherardo; Lania, Andrea; Uccella, Silvia; Di Tommaso, Luca; Ferreli, Fabio; Malvezzi, Luca; Spriano, Giuseppe; Mercante, Giuseppe. - In: REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS. - ISSN 1573-2606. - 25:2(2024), pp. 449-450. [10.1007/s11154-023-09851-z]

Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis (Reviews in Endocrine and Metabolic Disorders, (2023), 24, 6, (1205-1216), 10.1007/s11154-023-09845-x)

Russo Elena;
2024

Abstract

Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain. Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC. Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model. Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16–53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12–0.26; p = 0.43), -0.58 for LMR (95% CI -1.21–0.05; p = 0.06), and 0.01 (95% CI 0–0.01; p = 0.21) for PLR. Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
2024
Differentiated thyroid carcinoma; Lymphocyte-to-monocyte ratio; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Prognostic factor
01 Pubblicazione su rivista::01a Articolo in rivista
Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis (Reviews in Endocrine and Metabolic Disorders, (2023), 24, 6, (1205-1216), 10.1007/s11154-023-09845-x) / Russo, Elena; Guizzardi, Mathilda; Canali, Luca; Gaino, Francesca; Costantino, Andrea; Mazziotti, Gherardo; Lania, Andrea; Uccella, Silvia; Di Tommaso, Luca; Ferreli, Fabio; Malvezzi, Luca; Spriano, Giuseppe; Mercante, Giuseppe. - In: REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS. - ISSN 1573-2606. - 25:2(2024), pp. 449-450. [10.1007/s11154-023-09851-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1744343
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