L. Zhang et al. proposed novel immunotherapeutic strategies to limit the progression of inflammatory bowel diseases by targeting the interplay between the membrane-bound CD39 molecule and cellular metabolism — specifically, by increasing regulatory T-cell function through the modulation of glucose metabolism and suppressing pathogenic proinflammatory Th17 responses via the modulation of oxidative metabolism.
CD39 as a metabolic rheostat of immunoregulation / Barnaba, Vincenzo; Sozzani, Silvano. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 2042-0226. - 22:7(2025), pp. 806-808. [10.1038/s41423-025-01302-w]
CD39 as a metabolic rheostat of immunoregulation
Barnaba, Vincenzo
Primo
;Sozzani, SilvanoUltimo
Writing – Review & Editing
2025
Abstract
L. Zhang et al. proposed novel immunotherapeutic strategies to limit the progression of inflammatory bowel diseases by targeting the interplay between the membrane-bound CD39 molecule and cellular metabolism — specifically, by increasing regulatory T-cell function through the modulation of glucose metabolism and suppressing pathogenic proinflammatory Th17 responses via the modulation of oxidative metabolism.File allegati a questo prodotto
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