We aimed to investigate frailty in dementia with Lewy bodies (DLB) and its association with its core features. We retrospectively reviewed the clinical charts of 48 DLB outpatients. Frailty Index (FI) was generated by computing 39 age-related, multidimensional clinical deficits. FI scores varied from 0.08 to 0.54, with a median value of 0.26. FI showed a correlation with the severity of parkinsonism and visuo-spatial impairment, suggesting that some DLB features might be more influenced by frailty, whereas others, such as visual hallucinations, fluctuations, REM-behavior-disorder, seem not. Frailty may contribute to phenotypic variability in DLB; this study could inform future research aimed at clarifying the role of frailty in DLB.
Exploring frailty in dementia with Lewy bodies: A pilot, cross-sectional study / D'Antonio, Fabrizia; Panigutti, Massimiliano; Teghil, Alice; Blasi, Marco Toccaceli; Salzillo, Martina; Talarico, Giusi; Monti, Micaela Sepe; Bruno, Giuseppe; Canevelli, Marco. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - Online ahead of print:(2025), pp. 1-7. [10.1177/13872877251352076]
Exploring frailty in dementia with Lewy bodies: A pilot, cross-sectional study
D'Antonio, Fabrizia;Panigutti, Massimiliano;Teghil, Alice;Blasi, Marco Toccaceli;Salzillo, Martina;Monti, Micaela Sepe;Canevelli, Marco
2025
Abstract
We aimed to investigate frailty in dementia with Lewy bodies (DLB) and its association with its core features. We retrospectively reviewed the clinical charts of 48 DLB outpatients. Frailty Index (FI) was generated by computing 39 age-related, multidimensional clinical deficits. FI scores varied from 0.08 to 0.54, with a median value of 0.26. FI showed a correlation with the severity of parkinsonism and visuo-spatial impairment, suggesting that some DLB features might be more influenced by frailty, whereas others, such as visual hallucinations, fluctuations, REM-behavior-disorder, seem not. Frailty may contribute to phenotypic variability in DLB; this study could inform future research aimed at clarifying the role of frailty in DLB.| File | Dimensione | Formato | |
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