The multifaceted role of hyaluronic acid in dentistry

Uvod: Poznato je da lokalni tretmani efikasno omogućavaju da visoke doze lekova direktno dospeju u meka tkiva gingive i parodontalni ligament, kao i u tvrde strukture kao što su alveolarna kost i cement. Pored svoje dobro utvrđene uloge u promovisanju zarastanja nakon stomatoloških procedura, hijaluronska kiselina (HA) je sada prepoznata kao održiva potporna terapija za hronična upalna stanja.

Background: Topical treatments are known to effectively deliver high doses of drugs directly to both the soft tissues of the gums and periodontal ligament, as well as to the hard structures like the alveolar bone and cementum. In addition to its well-established role in promoting healing post dental procedures, hyaluronic acid (HA) is now being recognized as a viable supportive therapy for chronic inflammatory conditions. Materijal and Methods: Our study was conducted to systematically review the available literature on two fronts: the efficacy of HA as an adjunctive treatment for chronic inflammation and the benefits of HA in dental healing. We searched PubMed, Google Scholar, and Ovid using a combination of keywords and MeSH terms; Results: from the 28 studies selected based on our inclusion criteria, which covered three papers related to gingivitis, thirteen to chronic periodontitis, seven to dental surgeries (including implants and sinus lifts), and three to oral ulcers. Conclusions: we found that topical HA application not only significantly aids postoperative dental recovery but also bodes well among patients with chronic gingival/periodontal inflammation and those suffering from oral ulcers.