“Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes: a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful, or potentially harmful, consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal.” (ULTRACET, acetaminophen/tramadol hydrochloride fixed-dose combination, FDA NDA#021123, SUPPL-15, 2023)
A call to develop tramadol enantiomer for overcoming the tramadol crisis by reducing addiction / D'Acquarica, Ilaria; Agranat, Israel. - In: FUTURE MEDICINAL CHEMISTRY. - ISSN 1756-8919. - 17:5(2025), pp. 505-507. [10.1080/17568919.2025.2463314]
A call to develop tramadol enantiomer for overcoming the tramadol crisis by reducing addiction
D'Acquarica, Ilaria
;
2025
Abstract
“Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes: a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful, or potentially harmful, consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal.” (ULTRACET, acetaminophen/tramadol hydrochloride fixed-dose combination, FDA NDA#021123, SUPPL-15, 2023)| File | Dimensione | Formato | |
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