Enhanced fluorescence detection of tau protein using photonic crystal-based biochips: a novel tool for Alzheimer's disease diagnostics

In this study, we present an innovative approach for the detection of Tau protein, a key biomarker of Alzheimer disease, using enhanced fluorescence detection. The methodology utilizes a bio-conjugation process to adapt 1D photonic crystal surface for precise molecular recognition. Our results demonstrate the successful detection of Tau protein in a simple environment, with a detection limit of 0.5ng/mL and a quantification limit of 1.2ng/mL. This work introduces optical disposable biochips as a novel diagnostic tool for Alzheimer disease and related neurodegenerative disorders, addressing critical challenges in biomarker detection and paving the way for advancements in therapeutic development.