Background: The impact of novel photon-counting detector (PCD)-CT technology on in-vivo radiomics is not fully understood. This study aimed to compare the intra-individual stability and reproducibility of pericoronary adipose tissue (PCAT) radiomic features between PCD-CT and energy-integrating detector (EID)-CT in patients undergoing coronary CT angiography (CCTA) on both systems. Methods: Patients undergoing clinically indicated CCTA on an EID-CT were prospectively enrolled for research PCD-CCTA within 30 days. Image acquisition parameters were standardized; PCD-CT datasets were reconstructed both down-sampled to 0.6 mm to match the clinical scan (PCD-CTDS) and at 0.2 mm ultrahigh-resolution mode (PCD-CTUHR). Automatic PCAT segmentation was performed; a total of 110 radiomic feature classes were extracted and compared across the three datasets (EID-CT, PCD-CTDS, and PCD-CDUHR). Feature stability was assessed using paired t-test filtered for false discoveries using Benjamini–Hochberg method, and reproducibility using intraclass correlation coefficient (ICC). Results: A total of 42 patients (34 male [81.0 %]; 67.9 ± 7.6 years) were included. Feature stability was 91 % for EID-CT vs. PCD-CTDS, but decreased for UHR datasets (EID-CT vs. PCD-CTUHR: 55 %; PCD-CTDS vs. PCD-CTUHR: 51 %). However, inter-scanner reproducibility was poor in both comparisons (EID-CT vs. PCD-CTDS median ICC: 0.43 [0.03–0.69]; EID-CT vs. PCD-CTUHR: 0.29 [0.01–0.51]). Nevertheless, reproducibility improved within PCD-CT datasets (PCD-CTDS vs. PCD-CTUHR: 0.72 [0.48–0.83]), regardless of the difference in slice thickness. Conclusions: Most PCAT radiomic features remained stable between EID-CT and PCD-CTDS, although inter-scanner reproducibility was poor, emphasizing the significant impact of detector technology. Conversely, reproducibility of features within PCD-CT datasets showed more consistent results, even when comparing standard to UHR.

Intra-individual radiomic analysis of pericoronary adipose tissue: Photon-counting detector vs energy-integrating detector CT angiography / Kravchenko, Dmitrij; Vecsey-Nagy, Milan; Varga-Szemes, Akos; Hagar, Muhammad Taha; Schoepf, U Joseph; Gnasso, Chiara; Zsarnóczay, Emese; O'Doherty, Jim; Caruso, Damiano; Laghi, Andrea; Emrich, Tilman; Tremamunno, Giuseppe. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 1874-1754. - 420:(2025). [10.1016/j.ijcard.2024.132749]

Intra-individual radiomic analysis of pericoronary adipose tissue: Photon-counting detector vs energy-integrating detector CT angiography

Caruso, Damiano;Laghi, Andrea;Tremamunno, Giuseppe
Ultimo
2025

Abstract

Background: The impact of novel photon-counting detector (PCD)-CT technology on in-vivo radiomics is not fully understood. This study aimed to compare the intra-individual stability and reproducibility of pericoronary adipose tissue (PCAT) radiomic features between PCD-CT and energy-integrating detector (EID)-CT in patients undergoing coronary CT angiography (CCTA) on both systems. Methods: Patients undergoing clinically indicated CCTA on an EID-CT were prospectively enrolled for research PCD-CCTA within 30 days. Image acquisition parameters were standardized; PCD-CT datasets were reconstructed both down-sampled to 0.6 mm to match the clinical scan (PCD-CTDS) and at 0.2 mm ultrahigh-resolution mode (PCD-CTUHR). Automatic PCAT segmentation was performed; a total of 110 radiomic feature classes were extracted and compared across the three datasets (EID-CT, PCD-CTDS, and PCD-CDUHR). Feature stability was assessed using paired t-test filtered for false discoveries using Benjamini–Hochberg method, and reproducibility using intraclass correlation coefficient (ICC). Results: A total of 42 patients (34 male [81.0 %]; 67.9 ± 7.6 years) were included. Feature stability was 91 % for EID-CT vs. PCD-CTDS, but decreased for UHR datasets (EID-CT vs. PCD-CTUHR: 55 %; PCD-CTDS vs. PCD-CTUHR: 51 %). However, inter-scanner reproducibility was poor in both comparisons (EID-CT vs. PCD-CTDS median ICC: 0.43 [0.03–0.69]; EID-CT vs. PCD-CTUHR: 0.29 [0.01–0.51]). Nevertheless, reproducibility improved within PCD-CT datasets (PCD-CTDS vs. PCD-CTUHR: 0.72 [0.48–0.83]), regardless of the difference in slice thickness. Conclusions: Most PCAT radiomic features remained stable between EID-CT and PCD-CTDS, although inter-scanner reproducibility was poor, emphasizing the significant impact of detector technology. Conversely, reproducibility of features within PCD-CT datasets showed more consistent results, even when comparing standard to UHR.
2025
Computed tomography angiography; Energy-integrating detector; Pericoronary adipose tissue, photon-counting detector; Radiomics; Reproducibility of results
01 Pubblicazione su rivista::01a Articolo in rivista
Intra-individual radiomic analysis of pericoronary adipose tissue: Photon-counting detector vs energy-integrating detector CT angiography / Kravchenko, Dmitrij; Vecsey-Nagy, Milan; Varga-Szemes, Akos; Hagar, Muhammad Taha; Schoepf, U Joseph; Gnasso, Chiara; Zsarnóczay, Emese; O'Doherty, Jim; Caruso, Damiano; Laghi, Andrea; Emrich, Tilman; Tremamunno, Giuseppe. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 1874-1754. - 420:(2025). [10.1016/j.ijcard.2024.132749]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1731488
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