Background/Objectives: Infectious diseases represent a serious threat due to rising antimi- crobial resistance, particularly among multidrug-resistant bacteria and influenza viruses. Metal-based complexes, such as N-heterocyclic carbene–gold (NHC–gold) complexes, show promising therapeutic potential due to their ability to inhibit various pathogens. Methods: Eight NHC–gold complexes were synthesized and tested for antibacterial activity against Escherichia coli, Enterococcus faecalis, Staphy- lococcus aureus, and for anti-influenza activity in lung and bronchial epithelial cells infected with influenza virus A/H1N1. Antibacterial activity was assessed through the determination of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC), while the viral load was quantified using qRT-PCR. Results: Complexes 3, 4, and 6 showed significant antibacterial activity at concentrations of 10–20 μg/mL. Additionally, these complexes significantly reduced viral load, with complexes 3 and 4 markedly inhibiting replication. Conclusions: These findings support the potential use of NHC–gold complexes in combined antimicrobial and antiviral therapies, representing an attractive option for fighting resistant infections.

Antibacterial and anti-influenza activities of N-Heterocyclic Carbene–gold complexes / Pellegrino, Michele; Checconi, Paola; 1, Jessica Ceramella; Prezioso, Carla; Limongi, Dolores; Marra, Maria; Mariconda, Annaluisa; Catalano, Alessia; DE ANGELIS, Marta; Nencioni, Lucia; Stefania Sinicropi, Maria; Longo and Stefano Aquaro, Pasquale. - 17:12(2024), pp. 1-13. [10.3390/ph17121680]

Antibacterial and anti-influenza activities of N-Heterocyclic Carbene–gold complexes

Paola Checconi
;
Carla Prezioso;Dolores Limongi;Marta De Angelis;Lucia Nencioni;
2024

Abstract

Background/Objectives: Infectious diseases represent a serious threat due to rising antimi- crobial resistance, particularly among multidrug-resistant bacteria and influenza viruses. Metal-based complexes, such as N-heterocyclic carbene–gold (NHC–gold) complexes, show promising therapeutic potential due to their ability to inhibit various pathogens. Methods: Eight NHC–gold complexes were synthesized and tested for antibacterial activity against Escherichia coli, Enterococcus faecalis, Staphy- lococcus aureus, and for anti-influenza activity in lung and bronchial epithelial cells infected with influenza virus A/H1N1. Antibacterial activity was assessed through the determination of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC), while the viral load was quantified using qRT-PCR. Results: Complexes 3, 4, and 6 showed significant antibacterial activity at concentrations of 10–20 μg/mL. Additionally, these complexes significantly reduced viral load, with complexes 3 and 4 markedly inhibiting replication. Conclusions: These findings support the potential use of NHC–gold complexes in combined antimicrobial and antiviral therapies, representing an attractive option for fighting resistant infections.
2024
antimicrobials; influenza virus; drug resistance; n-heterocyclic carbene–gold complexes; metal-based therapeutics
01 Pubblicazione su rivista::01a Articolo in rivista
Antibacterial and anti-influenza activities of N-Heterocyclic Carbene–gold complexes / Pellegrino, Michele; Checconi, Paola; 1, Jessica Ceramella; Prezioso, Carla; Limongi, Dolores; Marra, Maria; Mariconda, Annaluisa; Catalano, Alessia; DE ANGELIS, Marta; Nencioni, Lucia; Stefania Sinicropi, Maria; Longo and Stefano Aquaro, Pasquale. - 17:12(2024), pp. 1-13. [10.3390/ph17121680]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1731423
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