Type 3 innate lymphoid cells (ILC3s) are key regulators of intestinal homeostasis and epithelial barrier integrity. In this issue of the JCI, Cao and colleagues found that a sensor of endoplasmic reticulum (ER) stress, the inositol-requiring kinase 1α/X-box–binding protein 1 (IRE1α/XBP1) pathway, fine-tuned the functions of ILC3s. Activation of IRE1α and XBP1 in ILC3s limited intestinal inflammation in mice and correlated with the efficacy of ustekinumab, an IL-12/IL-23 blocker, in patients with Crohn’s disease. These results advance our understanding in the use of ILCs as biomarkers not only to predict disease outcomes but also to indicate the response to biologicals in patients with inflammatory bowel disease.

A little ER stress isn't bad: the IRE1α/XBP1 pathway shapes ILC3 functions during intestinal inflammation / Fionda, Cinzia; Sciume', Giuseppe. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 1558-8238. - 134:13(2024). [10.1172/JCI182204]

A little ER stress isn't bad: the IRE1α/XBP1 pathway shapes ILC3 functions during intestinal inflammation

Fionda, Cinzia
Primo
;
Sciume', Giuseppe
Ultimo
2024

Abstract

Type 3 innate lymphoid cells (ILC3s) are key regulators of intestinal homeostasis and epithelial barrier integrity. In this issue of the JCI, Cao and colleagues found that a sensor of endoplasmic reticulum (ER) stress, the inositol-requiring kinase 1α/X-box–binding protein 1 (IRE1α/XBP1) pathway, fine-tuned the functions of ILC3s. Activation of IRE1α and XBP1 in ILC3s limited intestinal inflammation in mice and correlated with the efficacy of ustekinumab, an IL-12/IL-23 blocker, in patients with Crohn’s disease. These results advance our understanding in the use of ILCs as biomarkers not only to predict disease outcomes but also to indicate the response to biologicals in patients with inflammatory bowel disease.
2024
ILC, ER Stress, Colitis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
A little ER stress isn't bad: the IRE1α/XBP1 pathway shapes ILC3 functions during intestinal inflammation / Fionda, Cinzia; Sciume', Giuseppe. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 1558-8238. - 134:13(2024). [10.1172/JCI182204]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1729675
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