Introduction: Nanoparticles have orchestrated a paradigm shift in the landscape of cancer diagnosis and therapy, presenting a multifaceted approach to tackle the intricacies of malignancies. This comprehensive exposition delves deep into the forefront of nanomedicine, elucidating pivotal strategies and innovations primed to metamorphose the domain of cancer management. Methodology: Nanoparticles transcend traditional boundaries, enabling meticulous, site-specific drug release while minimizing systemic toxicity. Intricately designed activation mechanisms, encompassing pH and enzymatic responsivity, along with concentration-dependent strategies, exploit the distinctive attributes of cancer cells, heralding an era characterized by unprecedented therapeutic precision. The pervasive influence of nanotechnology extends to diagnostics, unlocking the realm of early disease detection and personalized treatment. These versatile agents bestow empowering capabilities upon sensitive imaging modalities, affording real-time monitoring and theranostic potential. Results: This exposition showcases the evolution of cutting-edge nanoplatforms, bridging the chasm between diagnosis and therapy, thereby redefining the confines of cancer care. This review elucidates strategies to combat drug resistance, a perennial challenge within cancer management. By targeting efflux transporters, modulating apoptotic pathways, and countering hypoxia-induced resistance, nanoparticles stand at the vanguard of therapeutic innovation, poised to reinvigorate treatment efficacy. Discussion & Conclusion: Moreover, this exposé underscores the imminent clinical translation of nanoparticle-based drugs, accentuating their potential to metamorphose the landscape of cancer management. Liposomal vaccines, nano-pharmaceuticals, and nanochemodrugs, currently navigating the crucible of clinical trials, bear immense promise in advancing the realm of precision medicine. In this epoch of precision medicine, nanoparticle-fueled innovations stand poised to propel cancer diagnosis and therapy to unprecedented peaks.

Nanoparticle-based biomolecules in cancer diagnosis, therapy, drug delivery and prognosis / Sv, S.; Augustine, D.; Hosmani, J.; Pagnoni, F.; Reda, R.; Testarelli, L.; Patil, S.. - In: FRONTIERS IN DENTAL MEDICINE. - ISSN 2673-4915. - 5:(2024). [10.3389/fdmed.2024.1482166]

Nanoparticle-based biomolecules in cancer diagnosis, therapy, drug delivery and prognosis

Reda R.
Data Curation
;
Testarelli L.
Penultimo
Supervision
;
2024

Abstract

Introduction: Nanoparticles have orchestrated a paradigm shift in the landscape of cancer diagnosis and therapy, presenting a multifaceted approach to tackle the intricacies of malignancies. This comprehensive exposition delves deep into the forefront of nanomedicine, elucidating pivotal strategies and innovations primed to metamorphose the domain of cancer management. Methodology: Nanoparticles transcend traditional boundaries, enabling meticulous, site-specific drug release while minimizing systemic toxicity. Intricately designed activation mechanisms, encompassing pH and enzymatic responsivity, along with concentration-dependent strategies, exploit the distinctive attributes of cancer cells, heralding an era characterized by unprecedented therapeutic precision. The pervasive influence of nanotechnology extends to diagnostics, unlocking the realm of early disease detection and personalized treatment. These versatile agents bestow empowering capabilities upon sensitive imaging modalities, affording real-time monitoring and theranostic potential. Results: This exposition showcases the evolution of cutting-edge nanoplatforms, bridging the chasm between diagnosis and therapy, thereby redefining the confines of cancer care. This review elucidates strategies to combat drug resistance, a perennial challenge within cancer management. By targeting efflux transporters, modulating apoptotic pathways, and countering hypoxia-induced resistance, nanoparticles stand at the vanguard of therapeutic innovation, poised to reinvigorate treatment efficacy. Discussion & Conclusion: Moreover, this exposé underscores the imminent clinical translation of nanoparticle-based drugs, accentuating their potential to metamorphose the landscape of cancer management. Liposomal vaccines, nano-pharmaceuticals, and nanochemodrugs, currently navigating the crucible of clinical trials, bear immense promise in advancing the realm of precision medicine. In this epoch of precision medicine, nanoparticle-fueled innovations stand poised to propel cancer diagnosis and therapy to unprecedented peaks.
2024
cancer diagnosis; cancer therapy; liposomal vaccines; nano-pharmaceuticals; nanochemodrugs; nanoparticles; prognosis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Nanoparticle-based biomolecules in cancer diagnosis, therapy, drug delivery and prognosis / Sv, S.; Augustine, D.; Hosmani, J.; Pagnoni, F.; Reda, R.; Testarelli, L.; Patil, S.. - In: FRONTIERS IN DENTAL MEDICINE. - ISSN 2673-4915. - 5:(2024). [10.3389/fdmed.2024.1482166]
File allegati a questo prodotto
File Dimensione Formato  
SV_Nanoparticle_2024.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 387.41 kB
Formato Adobe PDF
387.41 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1729655
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact