The neuropeptide Substance P (SP) and its preferred Neurokinin1 Receptor (NK1R) are known to participate in the physiopathology of neurodegenerative diseases and mainly exert a neuroprotective role. In the present work, we have described the involvement of SP and NK1R in Amyotrophic Lateral Sclerosis (ALS). This was demonstrated by the detection of altered levels of SP in the brain, spinal cord and cerebrospinal fluid (CSF) of patients and preclinical models of ALS, and by its ability to inhibit excitotoxicity-induced neurodegeneration in ALS animal models. These data are supported by results indicating an excitatory effect of SP at the motor neuron (MN) level, which promotes locomotor activity. ALS patients are characterized by a differential susceptibility to MNs degeneration, since sphincters and extraocular muscles are classically spared. It is hypothesized that SP may play a role in the maintenance of the ocular system and the innervation of the pelvic floor by contributing directly or indirectly to the selective resistance of this subset of MNs.

Perspective role of substance P in amyotrophic lateral sclerosis: from neuronal vulnerability to neuroprotection / Tirassa, P.; Rosso, P.; Fico, E.; Marenco, M.; Mallone, F.; Gharbiya, M.; Lambiase, A.; Severini, C.. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - 167:(2024), pp. 1-9. [10.1016/j.neubiorev.2024.105914]

Perspective role of substance P in amyotrophic lateral sclerosis: from neuronal vulnerability to neuroprotection

Marenco M.;Mallone F.;Gharbiya M.;Lambiase A.
Penultimo
;
2024

Abstract

The neuropeptide Substance P (SP) and its preferred Neurokinin1 Receptor (NK1R) are known to participate in the physiopathology of neurodegenerative diseases and mainly exert a neuroprotective role. In the present work, we have described the involvement of SP and NK1R in Amyotrophic Lateral Sclerosis (ALS). This was demonstrated by the detection of altered levels of SP in the brain, spinal cord and cerebrospinal fluid (CSF) of patients and preclinical models of ALS, and by its ability to inhibit excitotoxicity-induced neurodegeneration in ALS animal models. These data are supported by results indicating an excitatory effect of SP at the motor neuron (MN) level, which promotes locomotor activity. ALS patients are characterized by a differential susceptibility to MNs degeneration, since sphincters and extraocular muscles are classically spared. It is hypothesized that SP may play a role in the maintenance of the ocular system and the innervation of the pelvic floor by contributing directly or indirectly to the selective resistance of this subset of MNs.
2024
amyotrophic lateral sclerosis; motor neuron susceptibility; neuroprotection; substance P; visual system
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Perspective role of substance P in amyotrophic lateral sclerosis: from neuronal vulnerability to neuroprotection / Tirassa, P.; Rosso, P.; Fico, E.; Marenco, M.; Mallone, F.; Gharbiya, M.; Lambiase, A.; Severini, C.. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - 167:(2024), pp. 1-9. [10.1016/j.neubiorev.2024.105914]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1728558
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