Paraneoplastic Raynaud's phenomenon associated to astrocytoma

Raynaud’s phenomenon (RP) is a type of vascular disease characterized by vasoconstriction of the cutaneous arterioles in response to provoking factors such as exposure to cold temperature or emotional stress. It can be categorized as either primary or secondary. In patients affected by primary RP, the majority of cases, no underlying disease can be detected. Conversely, secondary RP is associated with a disease, most commonly connective tissue disorders such as systemic sclerosis and systemic lupus erythematosus. Further causes include drugs, occupational diseases and endocrine disorders [1—3]. Malignancy is a rarely reported cause of secondary RP. Paraneoplastic RP has been described in patients affected by malignancy. In this report, we describe a 25-year-old woman with RP attacks that occurred before diagnosis of astrocytoma and disappeared after surgical resection of the brain mass.