Singh et al. propose that loss α-gal expression was naturally selected in ancestral primates based on enhanced resistance to bacterial sepsis due to α-gal “removal” from IgG. Despite early onset of reproductive senescence in absence of α-gal, mathematical modeling suggests that the survival advantage against infection outweighed this trade-off.

Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis / Singh, S., Thompson, J.A., Yilmaz, B., Li, H., Weis, S., Sobral, D., Truglio, M., Aires da Silva, F., Aguiar, S., Carlos, A.R., Rebelo, S., Cardoso, S., Gjini, E., Nunez, G., Soares, M.P.. - In: CELL HOST & MICROBE. - ISSN 1931-3128. - 29:3(2021). [10.1016/j.chom.2020.12.017]

Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis

Truglio M.;
2021

Abstract

Singh et al. propose that loss α-gal expression was naturally selected in ancestral primates based on enhanced resistance to bacterial sepsis due to α-gal “removal” from IgG. Despite early onset of reproductive senescence in absence of α-gal, mathematical modeling suggests that the survival advantage against infection outweighed this trade-off.
2021
glycans; human evolution; IgG effector function; infection; microbiota; natural antibodies; reproductive senescence; sepsis; trade-off; α-gal
01 Pubblicazione su rivista::01a Articolo in rivista
Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis / Singh, S., Thompson, J.A., Yilmaz, B., Li, H., Weis, S., Sobral, D., Truglio, M., Aires da Silva, F., Aguiar, S., Carlos, A.R., Rebelo, S., Cardoso, S., Gjini, E., Nunez, G., Soares, M.P.. - In: CELL HOST & MICROBE. - ISSN 1931-3128. - 29:3(2021). [10.1016/j.chom.2020.12.017]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1725832
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