Protein amyloid fibrils relevant for neurodegenerative diseases have been irradiated with continuous wave 0.6 THz radiation for minutes. The effect on protein hydration and on the stability of amyloid fibrils has been monitored with ATR-FTIR (in hydrated environment and low-field condition) and with atomic force microscopy-assisted IR nano-spectroscopy (in dry environment and high-field condition), finding opposite effects on the inter-molecular aggregation state.
Effect of 0.6 THz irradiaton on protein fibrils monitored by mid-infrared nano-spectroscopy / Intze, Antonia; Temperini, Maria Eleonora; Gregori, Giorgio; Verde, Federica; Ortolani, Michele; Giliberti, Valeria. - 5:(2024), pp. 1-2. (Intervento presentato al convegno 2024 49th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) tenutosi a Perth, Australia) [10.1109/irmmw-thz60956.2024.10697815].
Effect of 0.6 THz irradiaton on protein fibrils monitored by mid-infrared nano-spectroscopy
Intze, Antonia;Temperini, Maria Eleonora;Gregori, Giorgio;Verde, Federica;Ortolani, Michele;Giliberti, Valeria
2024
Abstract
Protein amyloid fibrils relevant for neurodegenerative diseases have been irradiated with continuous wave 0.6 THz radiation for minutes. The effect on protein hydration and on the stability of amyloid fibrils has been monitored with ATR-FTIR (in hydrated environment and low-field condition) and with atomic force microscopy-assisted IR nano-spectroscopy (in dry environment and high-field condition), finding opposite effects on the inter-molecular aggregation state.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
