Proliferative vitreoretinopathy (PVR) is a pathological process characterized by the formation of fibrotic membranes that contract and lead to recurrent retinal detachment. Pars plana vitrectomy (PPV) is the primary treatment, but recurrence rates remain high, as surgery does not address the underlying molecular mechanisms driving fibrosis. Despite several proposed pharmacological interventions, no approved therapies exist, partly due to challenges in conducting preclinical and in vivo studies for ethical and safety reasons. This review explores the potential of computational models and Digital Twins, which are increasingly gaining attention in medicine. These tools could enable the development of progressively complex PVR models, from basic simulations to patient-specific Digital Twins. Nintedanib, a tyrosine kinase inhibitor targeting PDGFR, VEGFR, and FGFR, is presented as a prototype for computational models to simulate its effects on fibrotic pathways in virtual patient cohorts. Although still in its early stages, the integration of computational models and Digital Twins offers promising avenues for improving PVR management through more personalized therapeutic strategies.

Proliferative vitreoretinopathy in retinal detachment: perspectives on building a digital twin model using Nintedanib / Visioli, Giacomo; Romaniello, Annalisa; Spinoglio, Leonardo; Albanese, GIUSEPPE MARIA; Iannetti, Ludovico; Gagliardi, OSCAR MATTEO; Lambiase, Alessandro; Gharbiya, Magda. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:20(2024), pp. 1-14. [10.3390/ijms252011074]

Proliferative vitreoretinopathy in retinal detachment: perspectives on building a digital twin model using Nintedanib

Visioli Giacomo
Primo
Writing – Review & Editing
;
Romaniello Annalisa
Secondo
Writing – Original Draft Preparation
;
Spinoglio Leonardo
Writing – Review & Editing
;
Albanese Giuseppe Maria
Writing – Review & Editing
;
Iannetti Ludovico
Validation
;
Gagliardi Oscar Matteo
Visualization
;
Lambiase Alessandro
Penultimo
Supervision
;
Gharbiya Magda
Ultimo
Conceptualization
2024

Abstract

Proliferative vitreoretinopathy (PVR) is a pathological process characterized by the formation of fibrotic membranes that contract and lead to recurrent retinal detachment. Pars plana vitrectomy (PPV) is the primary treatment, but recurrence rates remain high, as surgery does not address the underlying molecular mechanisms driving fibrosis. Despite several proposed pharmacological interventions, no approved therapies exist, partly due to challenges in conducting preclinical and in vivo studies for ethical and safety reasons. This review explores the potential of computational models and Digital Twins, which are increasingly gaining attention in medicine. These tools could enable the development of progressively complex PVR models, from basic simulations to patient-specific Digital Twins. Nintedanib, a tyrosine kinase inhibitor targeting PDGFR, VEGFR, and FGFR, is presented as a prototype for computational models to simulate its effects on fibrotic pathways in virtual patient cohorts. Although still in its early stages, the integration of computational models and Digital Twins offers promising avenues for improving PVR management through more personalized therapeutic strategies.
2024
proliferative vitreoretinopathy; computational models; digital twin; nintedanib; fibrosis; retinal detachment; signaling pathways; personalized medicine; ophthalmology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Proliferative vitreoretinopathy in retinal detachment: perspectives on building a digital twin model using Nintedanib / Visioli, Giacomo; Romaniello, Annalisa; Spinoglio, Leonardo; Albanese, GIUSEPPE MARIA; Iannetti, Ludovico; Gagliardi, OSCAR MATTEO; Lambiase, Alessandro; Gharbiya, Magda. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:20(2024), pp. 1-14. [10.3390/ijms252011074]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1722475
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